糖尿病、インスリン抵抗性、及び肥満症の治療のためのGIPペプチド・アナログ

Title:

糖尿病、インスリン抵抗性、及び肥満症の治療のためのGIPペプチド・アナログ

Document Type and Number:

Japanese Patent JP2008500280

Kind Code:

A

Abstract:

The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have enhanced resistance to degradation by the enzyme dipeptidyl peptidase IV (DPP IV). The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.

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Inventors:

Gold, Victor A.
Ohart, Finver Paul Mary
Flat, peter raymond
Irwin, Nigel

Application Number:

JP2007500292A

Publication Date:

January 10, 2008

Filing Date:

February 25, 2005

Export Citation:

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Assignee:

University of Ulster

International Classes:

C07K14/47; A61K38/00; A61K38/22; A61P3/04; A61P3/06; A61P3/10; A61P9/12; C07K14/575

Foreign References:

WO2000058360A2

2000-10-05

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe

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