Title:
MAGE遺伝子の発現もしくはその作用を阻害するガンの治療方法
Document Type and Number:
Japanese Patent JP2008500362
Kind Code:
A
Abstract:
Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits MAGE gene expression or MAGE protein function. Preferably, the antagonist is an anti-MAGE antibody, an antisense molecule, an siRNA molecule, a molecule for forming a triplex nucleic acid molecule with a MAGE encoding polynucleotide, or a small molecule inhibitor of MAGE function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE gene expression of MAGE protein function.
Inventors:
Long Ray, Bee, Jack
Young, Bin
Young, Bin
Application Number:
JP2007515310A
Publication Date:
January 10, 2008
Filing Date:
May 26, 2005
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
A61K45/00; A61K31/7088; A61K31/713; A61K38/00; A61K39/395; A61K48/00; A61P13/10; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07K16/30; C12N15/113; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Takeshi Katsura
Mibu Yuko
Mibu Yuko