Title:
ユビキチンタンパク質に基づく人工結合タンパク質の生成
Document Type and Number:
Japanese Patent JP2008500953
Kind Code:
A
Abstract:
Proteins (A) of the ubiquitin-like protein superfamily that include at least one amino acid (aa) modification, at least in the surface-exposed region of the protein, so as to impart a binding specificity, for a predetermined binding partner, that is not present in the original protein are new. Proteins (A) of the ubiquitin-like protein superfamily that include at least one amino acid (aa) modification, at least in the surface-exposed region of the protein, so as to impart a binding specificity, for a predetermined binding partner, that is not present in the original protein are new. (A), or derived fragments or fusion proteins, retain the ubiquitin-like folding motif of the original protein, and the surface-exposed region includes at least one beta -fold region, optionally also a non-beta -fold region. An independent claim is also included for a method for preparing (A). ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Receptor or ligand blockade; targeted delivery of other effectors.
Inventors:
Feeder, Marx
Feeder, Ulrique
Rudolph the liner
Feeder, Ulrique
Rudolph the liner
Application Number:
JP2006529936A
Publication Date:
January 17, 2008
Filing Date:
May 27, 2004
Export Citation:
Assignee:
SCIL PROTEINS GMBH
International Classes:
C07K14/47; A61K38/00; A61P31/00; A61P35/00; A61P43/00; C07K1/22; C07K14/00; C07K19/00; C12N15/09; C12N15/10; C12P21/02; C40B40/02; G01N33/53; G01N33/543; G01N33/68
Domestic Patent References:
| JP2003504081A | 2003-02-04 |
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners