Title:
ドーパミン神経伝達のモジュレーターとしての新規な置換されたピペリジン
Document Type and Number:
Japanese Patent JP2008501748
Kind Code:
A
Abstract:
Disclosed are 4-phenyl-piperidin-4-ol derivatives of Formula 1, wherein; R1 Is selected from OSO2CF3, OSO2CH3, SO2CF3, COCH3, CN, OCF3, F, CI, and CF3; R2 occupies either the 2 or the 4-positlon of the phenyl ring; when R2 occupies the 2-position, R2 is selected from H, OH, NH2, F, CI, and CH3, when R2 occupies the 4-position, R2 is selected from H, CN, CF3, OH, NH2, F, Cl, Br, I, and CH3; R3 is selected from alky, allyl, CH2CH2OCH3, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, CH2CHF2, CH2CF3, 3,3,3-trifluoropropyl, and 4,4,4-trifluorobutyl; or a pharmaceutically acceptable salt thereof; with the proviso that R3 is not methyl when R1 is trifluoromethyl and R2 is hydrogen, when R1 is trifluromethyl and R2 is 4-chloro, and with the proviso that R3 is not n-propyl when R1 is trifluoromethyl and R2 is 4-fluoro. Also disclosed is the use of the compounds as defined above for the manufacture of a pharmaceutically active preparation for treating a disorder of the central nervous system.
Inventors:
Sonson, class
Swanson, Lars
Waters, Nicholas
Swanson, Lars
Waters, Nicholas
Application Number:
JP2007526288A
Publication Date:
January 24, 2008
Filing Date:
June 08, 2005
Export Citation:
Assignee:
Neurosearch Sweden Activola Get
International Classes:
C07D211/52; A61K31/451; A61P3/04; A61P15/08; A61P21/00; A61P25/00; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/30; A61P29/00; A61P39/02
Domestic Patent References:
| JP2003518096A | 2003-06-03 |
Foreign References:
| US3284457A | 1966-11-08 | |||
| FR1455825A | 1966-05-20 | |||
| US4132710A | 1979-01-02 |
Attorney, Agent or Firm:
Masaaki Ogura
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