Title:
血中トレーサ濃度の非侵襲測定システム
Document Type and Number:
Japanese Patent JP2008502377
Kind Code:
A
Abstract:
The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.
Inventors:
Dragos-Nikolae Pelligrad
Rosser spise
Timo Paulus
Rosser spise
Timo Paulus
Application Number:
JP2007514251A
Publication Date:
January 31, 2008
Filing Date:
May 20, 2005
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
A61B6/03; A61B5/055; A61B8/00; G01T1/161; G06F19/00
Domestic Patent References:
| JP2002540906A | 2002-12-03 |
Other References:
R. N. UPTON: "The two-compartment recirculatory pharmacokinetic modelDanintroduction to recirculatory pharmacokine", BRITISH JOURNAL OF ANAESTHESIA, vol. 92, no. 4, JPN7010002861, February 2004 (2004-02-01), pages 475 - 484, ISSN: 0001723184
SHALINI NARAYANA ET. AL,: "Construction of a Whole Body Blood Flow Model for Use in Positron Emission Tomography Imaging with [", JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, vol. Volume 25, Number 5, JPN6010052420, October 1997 (1997-10-01), pages 539 - 567, ISSN: 0001723185
GUNNAR BRIX ET. AL,: "Regional Blood Flow, Capillary Permeability, and Compartmental Volumes: Measurement with Dynamic CT-", RADIOLOGY, vol. 210(1), JPN6010052417, January 1999 (1999-01-01), pages 269 - 276, ISSN: 0001723186
PAUL S. TOFTS ET. AL,: "Estimating Kinetic Parameters From DynamicContrast-Enhanced T1-Weighted MRI of a DiffusableTracer: S", JOURNAL OF MAGNETIC RESONANCE IMAGING, vol. Volume 10, Issue 3, JPN6010052418, 1999, pages 223 - 232, ISSN: 0001723187
SHALINI NARAYANA ET. AL,: "Construction of a Whole Body Blood Flow Model for Use in Positron Emission Tomography Imaging with [", JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, vol. Volume 25, Number 5, JPN6010052420, October 1997 (1997-10-01), pages 539 - 567, ISSN: 0001723185
GUNNAR BRIX ET. AL,: "Regional Blood Flow, Capillary Permeability, and Compartmental Volumes: Measurement with Dynamic CT-", RADIOLOGY, vol. 210(1), JPN6010052417, January 1999 (1999-01-01), pages 269 - 276, ISSN: 0001723186
PAUL S. TOFTS ET. AL,: "Estimating Kinetic Parameters From DynamicContrast-Enhanced T1-Weighted MRI of a DiffusableTracer: S", JOURNAL OF MAGNETIC RESONANCE IMAGING, vol. Volume 10, Issue 3, JPN6010052418, 1999, pages 223 - 232, ISSN: 0001723187
Attorney, Agent or Firm:
Tadahiko Ito
Kosaku Sugimura
Shiro Fujitani
Kiyoshi Kuruma
Yoshiyuki Iwasa
Kosaku Sugimura
Shiro Fujitani
Kiyoshi Kuruma
Yoshiyuki Iwasa