Title:
ラミニン-5調節物質及びその使用
Document Type and Number:
Japanese Patent JP2008502588
Kind Code:
A
Abstract:
Described herein are methods of treating or preventing various diseases and disorders using modulators of laminin-5. Exemplary diseases and disorders are inflammatory bowel disease, including ulcerative colitis and Crohn's disease, as well as polycystic kidney disease and cancers associated with one or more of the aforementioned conditions. Exemplary laminin-5 modulators include monoclonal antibodies against the laminin-5 gamma2 chain and short interfering RNA (siRNA) sequences against nucleotide sequences encoding the laminin-5 gamma2 chain. Described are also combination treatments based on the administration of a laminin-5 modulator and at least one other therapeutic agent.
Inventors:
Maciasen, Ida Stenfeld
Bower, Michael Karl
Muller, Jörn Roland
Bower, Michael Karl
Muller, Jörn Roland
Application Number:
JP2006543368A
Publication Date:
January 31, 2008
Filing Date:
December 13, 2004
Export Citation:
Assignee:
NOVO NORDISK AKTIE SELSXAB
International Classes:
A61K45/00; A61K31/7088; A61K38/00; A61K38/39; A61K39/395; A61K48/00; A61P1/00; A61P13/12; A61P29/00; A61P35/00; C12N15/113; C07K16/18; C12N15/09
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Ryo Hashimoto
Tetsuya Kazama
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Ryo Hashimoto
Tetsuya Kazama