Title:
RNA依存性RNAウイルスポリメラーゼの阻害剤としてのC-プリンヌクレオシド類似体
Document Type and Number:
Japanese Patent JP2008502685
Kind Code:
A
Abstract:
The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C-nucleoside compounds of the present invention.
Inventors:
Bootla, gabor
Matsukos, Malcolm
Bart, Barcelien
Eldratop, Anne Bee
Matsukos, Malcolm
Bart, Barcelien
Eldratop, Anne Bee
Application Number:
JP2007516605A
Publication Date:
January 31, 2008
Filing Date:
June 10, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D487/04; A61K31/513; A61K31/519; A61K31/522; A61P1/16; A61P31/14; A61P43/00; C07D491/04; C07D491/048; C07D498/04
Foreign References:
| WO2004058792A1 | 2004-07-15 | |||
| WO2003093290A2 | 2003-11-13 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura