Title:
癌疾患修飾抗体
Document Type and Number:
Japanese Patent JP2008504226
Kind Code:
A
Abstract:
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
Inventors:
Young, David, S., F.
Hahn, Susan, Yi.
Setchet, Lisa, M.
Hahn, Susan, Yi.
Setchet, Lisa, M.
Application Number:
JP2007500024A
Publication Date:
February 14, 2008
Filing Date:
February 28, 2005
Export Citation:
Assignee:
Arias Research, Inc.
International Classes:
C07K16/30; A61K39/395; A61K51/10; A61P35/00; C07K16/18; C12N5/12; C12N5/18; C12N15/02; C12Q1/68; G01N33/574; C12P21/08
Other References:
JPN6010064215, Ｉｎｔ． Ｊ． Ｃａｎｃｅｒ， ７１（１９９７） ｐ．１０４９−１０５５
JPN6010064217, Ｊ． Ｕｒｏｌ．， １６５［５ Ｓｕｐｐｌ．］（２００１） ｐ．１６７−１６８（６８７）
JPN6010064217, Ｊ． Ｕｒｏｌ．， １６５［５ Ｓｕｐｐｌ．］（２００１） ｐ．１６７−１６８（６８７）
Attorney, Agent or Firm:
Kazunori Saito
Tetsuya Ito
Tetsuya Ito