Title:
CHK1の阻害に有用なビスアリール尿素誘導体
Document Type and Number:
Japanese Patent JP2008504283
Kind Code:
A
Abstract:
Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed. Formula (I).
Inventors:
Burgess, Lawrence Edward
Cook, adam wade
Fisher, Kimbael.
Gaudino, John Joseph
Shuractor, Stephen Tea.
Cook, adam wade
Fisher, Kimbael.
Gaudino, John Joseph
Shuractor, Stephen Tea.
Application Number:
JP2007518316A
Publication Date:
February 14, 2008
Filing Date:
June 24, 2005
Export Citation:
Assignee:
ICOS CORPORATION
International Classes:
C07D241/20; A61K31/4965; A61K31/497; A61K41/00; A61K45/00; A61K51/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D401/12; C07D405/12; C07D405/14
Domestic Patent References:
| JP2001526276A | 2001-12-18 | |||
| JPH09249628A | 1997-09-22 | |||
| JPH01163723A | 1989-06-28 |
Foreign References:
| WO2003101444A1 | 2003-12-11 | |||
| WO2002070494A1 | 2002-09-12 | |||
| WO2003022273A1 | 2003-03-20 | |||
| WO2003093250A2 | 2003-11-13 |
Attorney, Agent or Firm:
Yoshihiro Tsunoda
Yasu Furukawa
Toshio Nishitani
Yasu Furukawa
Toshio Nishitani