Title:
(1R,2R)-3-(3-ジメチルアミノ-1-エチル-2-メチル-プロピル)フェノールを含有する乱用防止経口投与形態物
Document Type and Number:
Japanese Patent JP2008504328
Kind Code:
A
Abstract:
The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredient and/or one or more pharmaceutically acceptable compounds (A) thereof, at least one synthetic and/or natural polymer (C), retarding adjuvants, optionally comprises additional physiologically compatible adjuvants (B), and optionally comprises a wax (D). The oral dosage form has a breaking resistance of at least 500 N, preferably at least 750 N. The dosage form contains at least one of the following abuse-preventing constituents (a)-(f); (a) at least one substance that irritates the nasal and/or pharyngeal cavity; (b) at least one viscosity-increasing agent; (c) at least one antagonist for the active ingredient having an abuse potential; (d) at least one emetic; (e) at least one colorant serving as an aversive agent, and; (f) at least one bitter substance.
Inventors:
Bartholomew, Johannes
Kugelmann, Heinrich
Kugelmann, Heinrich
Application Number:
JP2007518529A
Publication Date:
February 14, 2008
Filing Date:
June 29, 2005
Export Citation:
Assignee:
Grunenthal Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/135; A61K9/14; A61K9/20; A61K9/48; A61K47/34; A61K47/38; A61P25/02; A61P29/00
Domestic Patent References:
| JPH03501737A | 1991-04-18 |
Foreign References:
| WO2004037259A1 | 2004-05-06 | |||
| WO2004004693A1 | 2004-01-15 |
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo