Title:
ヒト化抗体
Document Type and Number:
Japanese Patent JP2008507253
Kind Code:
A
Abstract:
Novel humanized and chimeric antibodies, humanized antibody fragments, polypeptides sequences of such antibodies and derivatives thereof that specifically bind AF-20 are provided as well as methods for their manufacture. These humanized and chimeric antibodies, antibody fragments and polypeptide sequences are useful in the treatment of cancers that express AF-20, as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells that express AF-20.
Inventors:
Overback, Paul A
Gemel, jack
Gemel, jack
Application Number:
JP2006551695A
Publication Date:
March 13, 2008
Filing Date:
February 04, 2005
Export Citation:
Assignee:
NYMOX CORPORATION
International Classes:
C12N15/09; A61B19/00; A61K38/00; A61K38/43; A61K39/395; A61K45/00; A61K47/48; A61K49/00; A61K51/00; A61K51/10; A61P35/00; C07K7/06; C07K7/08; C07K16/30; C07K16/32; C07K16/44; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/574; A61K47/42
Domestic Patent References:
| JPH05503837A | 1993-06-24 | |||
| JPH05317082A | 1993-12-03 |
Other References:
JPN4007006555, Ｊ． Ｍｏｌ． Ｂｉｏｌ．, 1992, 第２２４巻, 第４８７−４９９頁
JPN4007006556, Ｂｉｏｔｈｅｒａｐｙ, 1996, 第１０巻, 第１３８４−１３９１頁
JPN6007008012, Ｐｒｏｔｅｉｎ Ｅｎｇ．， ｖｏｌ． ４， ｐｐ． ７７３−７８３ （１９９１）
JPN6010049259, Ｈｅｍａｔｏｌｏｇｙ， ｖｏｌ． ２９， ｐａｇｅｓ ８２−８９ （１９９９）
JPN4007006556, Ｂｉｏｔｈｅｒａｐｙ, 1996, 第１０巻, 第１３８４−１３９１頁
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JPN6010049259, Ｈｅｍａｔｏｌｏｇｙ， ｖｏｌ． ２９， ｐａｇｅｓ ８２−８９ （１９９９）
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho