Title:
NF-κBの阻害
Document Type and Number:
Japanese Patent JP2008507545
Kind Code:
A
Abstract:
Aminoacridines are inhibitors of NF-?B. Inhibiting NF-?B leads to reactivation of p53 in cancer cells with functionally blocked p53.
Inventors:
Gudkov, Andrei Buoy.
Grower, Katerina Buoy.
Grower, Katerina Buoy.
Application Number:
JP2007522754A
Publication Date:
March 13, 2008
Filing Date:
July 20, 2005
Export Citation:
Assignee:
Cleveland Clinic Foundation
International Classes:
A61K45/00; A61K31/473; A61K38/00; A61P29/00; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P43/00; C07D219/10
Domestic Patent References:
| JP2001131066A | 2001-05-15 |
Foreign References:
| WO2003074490A1 | 2003-09-12 |
Other References:
JPN6011019779; ＭｃＣｏｒｍｉｃｋ，Ｄ．Ｌ． ｅｔ ａｌ．: 'Ａｎｔｉｃａｒｃｉｎｏｇｅｎｉｃ ａｃｔｉｖｉｔｙ ｏｆ ｑｕｉｎａｃｒｉｎｅ ｉｎ ｔｈｅ ｒａｔ ｍａｍｍａｒｙ ｇｌａｎｄ' Ｃａｒｃｉｎｏｇｅｎｅｓｉｓ Ｖｏｌ．９，Ｎｏ．１, 198801, Ｐ．１７５-１７８
JPN6011019783; 堀江良一 外８名: '『成人Ｔ細胞性白血病に対する新規ＮＦ-kappaＢ阻害剤による分子標的療法の基礎的検討』' 日本癌学会総会記事 Ｖｏｌ．６２, 20030825, Ｐ．１５３
JPN6011019787; Ｌｅｊｅｕｎｅ，Ｆ．Ｊ． ｅｔ ａｌ．: 'Ｃｌｉｎｉｃａｌ ａｐｐｌｉｃａｔｉｏｎｓ ｏｆ ＴＮＦ-ａｌｐｈａ ｉｎ ｃａｎｃｅｒ' Ｃｕｒｒ． Ｏｐｉｎｉｏｎ Ｉｍｍｕｎｏｌ． Ｖｏｌ．１０，Ｎｏ．５, 199810, Ｐ．５７３-５７９
JPN6011069615; Ｍｕｒｚａ，Ａ． ｅｔ ａｌ．: 'Ｉｎｔｅｒａｃｔｉｏｎ ｏｆ ｔｈｅ ａｎｔｉｔｕｍｏｒ ｄｒｕｇ ９-ａｍｉｎｏａｃｒｉｄｉｎｅ ｗｉｔｈ ｇｕａｎｉｄｉｎｏｂｅｎｚｏａｔａｓｅ ｓｔｕｄｉｅｄ ｂｙ ｓｐｅｃｔｒｏｓｃｏｐｉｃ' Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３９，Ｎｏ．３４, 20000829, Ｐ．１０５５７-１０５６５
JPN6011069617; 木邑道夫: '"新規アクリジン誘導体のＥｔｈｉｄｉｕｍ-ＤＮＡ蛍光消光効果と抗がん活性"' 薬学雑誌 Ｖｏｌ．１１２，Ｎｏ．１２, 19921225, Ｐ．９１４-９１８
JPN6014052536; Ｏｎｃｏｇｅｎｅ Ｖｏｌ．１３， Ｎｏ．３, 1996, ６０９-６１６
JPN6014052537; 兵庫医科大学医学会雑誌 Ｖｏｌ．２６， Ｎｏ．３, 2001, １５５-１６７
JPN6014052538; 消化器癌の発生と進展 Ｖｏｌ．９, 1997, ４６５-４６８
JPN6011019783; 堀江良一 外８名: '『成人Ｔ細胞性白血病に対する新規ＮＦ-kappaＢ阻害剤による分子標的療法の基礎的検討』' 日本癌学会総会記事 Ｖｏｌ．６２, 20030825, Ｐ．１５３
JPN6011019787; Ｌｅｊｅｕｎｅ，Ｆ．Ｊ． ｅｔ ａｌ．: 'Ｃｌｉｎｉｃａｌ ａｐｐｌｉｃａｔｉｏｎｓ ｏｆ ＴＮＦ-ａｌｐｈａ ｉｎ ｃａｎｃｅｒ' Ｃｕｒｒ． Ｏｐｉｎｉｏｎ Ｉｍｍｕｎｏｌ． Ｖｏｌ．１０，Ｎｏ．５, 199810, Ｐ．５７３-５７９
JPN6011069615; Ｍｕｒｚａ，Ａ． ｅｔ ａｌ．: 'Ｉｎｔｅｒａｃｔｉｏｎ ｏｆ ｔｈｅ ａｎｔｉｔｕｍｏｒ ｄｒｕｇ ９-ａｍｉｎｏａｃｒｉｄｉｎｅ ｗｉｔｈ ｇｕａｎｉｄｉｎｏｂｅｎｚｏａｔａｓｅ ｓｔｕｄｉｅｄ ｂｙ ｓｐｅｃｔｒｏｓｃｏｐｉｃ' Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３９，Ｎｏ．３４, 20000829, Ｐ．１０５５７-１０５６５
JPN6011069617; 木邑道夫: '"新規アクリジン誘導体のＥｔｈｉｄｉｕｍ-ＤＮＡ蛍光消光効果と抗がん活性"' 薬学雑誌 Ｖｏｌ．１１２，Ｎｏ．１２, 19921225, Ｐ．９１４-９１８
JPN6014052536; Ｏｎｃｏｇｅｎｅ Ｖｏｌ．１３， Ｎｏ．３, 1996, ６０９-６１６
JPN6014052537; 兵庫医科大学医学会雑誌 Ｖｏｌ．２６， Ｎｏ．３, 2001, １５５-１６７
JPN6014052538; 消化器癌の発生と進展 Ｖｏｌ．９, 1997, ４６５-４６８
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita