Title:
5’-メチルチオアデノシンホスホリラーゼ及び5’メチルチオアデノシン/S-アデノシルホモシステインヌクレオシダーゼの阻害剤
Document Type and Number:
Japanese Patent JP2008508287
Kind Code:
A
Abstract:
Described are compounds of the general formula (I), VI and (VII). Also described are pharmaceutical compositions comprising the compounds identified. The compounds and pharmaceutical compositions described are inhibitors of 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) and/or 5'-methylthioadenosine phosphorylase (MTAP). Methods of treatment using the compounds and pharmaceutical compositions described are also provided for preventing and/or treating disease states and/or conditions by inhibiting MTAN and/or MTAP in patients.
Inventors:
Baboo, Yaraga Tsuda S
Camas, Vivekananda Pea
Morris, Giunia Phillip Y
Camas, Vivekananda Pea
Morris, Giunia Phillip Y
Application Number:
JP2007523709A
Publication Date:
March 21, 2008
Filing Date:
July 26, 2005
Export Citation:
Assignee:
Bio Christophe Pharmaceuticals Incorporated
International Classes:
C07D487/04; A61K31/519; A61K45/00; A61P31/04; A61P35/00; A61P43/00
Foreign References:
| WO2003080620A1 | 2003-10-02 | |||
| WO2004018496A1 | 2004-03-04 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura