Title:
HIV抑制1,2,4-トリアジン-6-オン誘導体
Document Type and Number:
Japanese Patent JP2008509200
Kind Code:
A
Abstract:
The present invention relates to HIV replication inhibitors of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1 to 4; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxyC1-6alkylcarbonyl substituted with C1-6alkyloxycarbonyl; R2 or R4 represents hydrogen; hydroxy; halo; optionally substituted C1-6alkyl; optionally substituted C2-6alkenyl; optionally substituted C2-6alkynyl; C3-7cycloalkyl; C1-6alkyloxy; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-4alkyl; polyhaloC1-4alkyloxy; polyhaloC1-4alkylthio; —S(═O)pR6; —NH—S(═O)pR6; —C(═O)R6; —NHC(═O)H; —C(═O)NHNH2; NHC(═O)R6; C(═NH)R6; or R7; R2a or R3 represents cyano; aminocarbonyl; amino; halo; NHR13; NR13R14; —C(═O)—NHR13; —C(═O)—NR13R14; —C(═O)—R15; —CH═N—NH—C(═O)—R16; optionally substituted C1-6alkyl; optionally substituted C1-6alkyloxy; optionally substituted C1-6alkyloxyC1-6alkyl; optionally substituted C2-6alkenyl; optionally substituted C2-6alkynyl; —C(═N—O—R8)—C1-4alkyl; R7 or —X3—R7; X1 or X2 represents —NR1—; —NH—NH—; —N═N—; —O—; —C(═O)—; —C1-4alkanediyl-; —CHOH—; —S—; —S(═O)p—; —X4—C1-4alkanediyl-; —C1-4alkanediyl-X4—; or —C1-4alkanediyl-X4—C1-4alkanediyl-; their use as a medicine, their use for the manufacture of a medicament for the treatment or the prevention of HIV infection; their processes for preparation and pharmaceutical compositions comprising them.
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Inventors:
Hoornert, Giorzyu, Joseph Cornelius
Kironda, Amuri
Jerez, Jiang
Reui, Paulus Johannes
De Jonghe, Marc Rene
Freyderk Franc Desire
Vinkers, Hendrik Marten
Coymans, Lucien Maria Henrix
Paul Jensen, Paul Adrien Jiang
Kironda, Amuri
Jerez, Jiang
Reui, Paulus Johannes
De Jonghe, Marc Rene
Freyderk Franc Desire
Vinkers, Hendrik Marten
Coymans, Lucien Maria Henrix
Paul Jensen, Paul Adrien Jiang
Application Number:
JP2007525304A
Publication Date:
March 27, 2008
Filing Date:
August 10, 2005
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D253/06; A61K31/53; A61P31/18
Domestic Patent References:
| JP2004519512A | 2004-07-02 | |||
| JP2002541246A | 2002-12-03 | |||
| JP2002511390A | 2002-04-16 | |||
| JP2002509920A | 2002-04-02 |
Foreign References:
| WO2004074266A1 | 2004-09-02 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heikichi Odashima
Heikichi Odashima