Title:
心毒性のない医薬化合物
Document Type and Number:
Japanese Patent JP2008509909
Kind Code:
A
Abstract:
The present invention relates to novel noncardiotoxic compounds and pharmaceutical compositions useful in the treatment of a variety of disorders including the treatment of depression, allergies, psychoses, cancer and gastrointestinal disorders. In particular, the present invention describes pharmaceutical compositions that mitigate life-threatening arrhythmias such as torsade de pointes. Torsade de pointes is a particular cardiac problem associated with many therapeutic agents and has been implicated as a possible cause of sudden death, particularly in those individuals with a past history of disturbances of cardiac rhythm, myocardial infarction, congenital repolarization abnormalities and cardiac risk factors such as hyperlipidemia and age. This arrhythmia is a variant of paroxysmal ventricular tachycardia associated with a prolonged QTc interval or prominent U waves on the ECG. Torsade de pointes is potentially lethal because it can progress to ventricular fibrillation, life-threatening arrhythmias or precipitate sudden death.
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Inventors:
Barbow, Donald El
Application Number:
JP2007525709A
Publication Date:
April 03, 2008
Filing Date:
August 09, 2005
Export Citation:
Assignee:
Williamsburg Holdings LLC
International Classes:
C07F9/24; A61K31/664; A61K31/665; A61K31/67; A61K31/675; A61P1/04; A61P9/06; A61P25/18; A61P25/24; A61P31/04; A61P35/00; A61P37/08; A61P43/00; C07F9/553; C07F9/572; C07F9/58; C07F9/59; C07F9/60; C07F9/6506; C07F9/6509; C07F9/6518; C07F9/6524; C07F9/6527; C07F9/653; C07F9/6533; C07F9/6544; C07F9/6547; C07F9/655; C07F9/6553; C07F9/6558; C07F9/6561
Domestic Patent References:
| JP2003509408A | 2003-03-11 | |||
| JP2002537262A | 2002-11-05 | |||
| JPH07300455A | 1995-11-14 | |||
| JP2000080094A | 2000-03-21 | |||
| JP2004523480A | 2004-08-05 | |||
| JPH01311091A | 1989-12-15 |
Foreign References:
| ES2006099A6 | 1989-04-01 | |||
| US4824850A | 1989-04-25 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho