Title:
粉末の被覆方法
Document Type and Number:
Japanese Patent JP2008512233
Kind Code:
A
Abstract:
The invention concerns a method for coating powdery solid active substances which includes the following steps: a) providing (2; 3; 4) a mixture comprising at least one coating agent wherein is dissolved a supercritical or subcritical fluid in conditions of temperature and pressure enabling said fluid to be maintained in supercritical or subcritical conditions; b) providing (7) individualized moving particles of at least one powdery solid active substance; c) contacting (8) the mixture and the moving individualized particles of active substance in conditions of temperature and pressure ensuring simultaneously expansion of the supercritical or subcritical fluid and its restoration to gaseous state, the atomization of the coating agent and its solidification around the moving individualized particles of active substance; d) separating and recuperating the coated particles (9). The invention also concerns coated microparticles, wherein the average size of the active substance core is less than 50 μm.
Inventors:
Calderone, marilyn
Rodier, Elisabeth
Rodier, Elisabeth
Application Number:
JP2007530742A
Publication Date:
April 24, 2008
Filing Date:
September 08, 2005
Export Citation:
Assignee:
PIERRE FABRE MEDICAMENT
International Classes:
B01J2/00; A23L1/00; A23L33/15; A61K8/11; A61K9/16; A61K9/50; B01J2/04; B01J3/00; B01J13/04
Domestic Patent References:
| JP2001129382A | 2001-05-15 | |||
| JP2001518391A | 2001-10-16 | |||
| JP2002505617A | 2002-02-19 | |||
| JP2001505190A | 2001-04-17 | |||
| JPH04260460A | 1992-09-16 | |||
| JP2002541320A | 2002-12-03 | |||
| JP2003534267A | 2003-11-18 | |||
| JP2000511110A | 2000-08-29 | |||
| JPH03504878A | 1991-10-24 |
Foreign References:
| WO2003086610A2 | 2003-10-23 | |||
| DE10233864A1 | 2003-07-17 | |||
| US20040079459A1 | 2004-04-29 |
Attorney, Agent or Firm:
Shoichi Hirose