Title:
アモルファスのアトルバスタチンを形成する方法
Document Type and Number:
Japanese Patent JP2008517992
Kind Code:
A
Abstract:
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
Inventors:
Anton John De Bettencourt The Third
Peter Robert Rose
Ifgeny Yuryevich Sharaev
George Joseph Quaritch
Karl Bernard Ziegler
Peter Robert Rose
Ifgeny Yuryevich Sharaev
George Joseph Quaritch
Karl Bernard Ziegler
Application Number:
JP2007538529A
Publication Date:
May 29, 2008
Filing Date:
October 12, 2005
Export Citation:
Assignee:
Warner-Lambert Company Limited Liability Company
International Classes:
C07D207/34; A61K31/40; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/34; A61K47/40; A61P3/06
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Shinsuke Arai
Hiroki Inuyama
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Shinsuke Arai
Hiroki Inuyama