COX阻害剤および5-LOX阻害剤の活性を助けるための可溶性エポキシドヒドロラーゼの阻害剤の使用

Title:

COX阻害剤および5-LOX阻害剤の活性を助けるための可溶性エポキシドヒドロラーゼの阻害剤の使用

Document Type and Number:

Japanese Patent JP2008526894

Kind Code:

A

Abstract:

The invention relates to methods, compositions, and uses of those compositions for making medicaments, for potentiating the beneficial effects of inhibitors of COX-1, COX-2, and 5-LOX, and reducing adverse effects, by also administering inhibitors of soluble epoxide hydrolase (“sEH”), with or without also administering one or more cis-epoxyeicosantrienoic acids. The invention further relates to the use of inhibitors of sEH as analgesics and to methods and compositions of epoxides of eicosapentaenoic acid and docosahexaenoic acid, optionally with an inhibitor of sEH, to reduce pain or inflammation or both.

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Inventors:

Hammock Bruce Dee.
Schmelzer Carla
Inseoguru Ahmet Bora

Application Number:

JP2007550577A

Publication Date:

July 24, 2008

Filing Date:

January 10, 2006

Export Citation:

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Assignee:

Legends of the University of California

International Classes:

A61K45/06; A61K31/196; A61K31/336; A61K31/365; A61K31/405; A61K31/415; A61K31/42; A61K31/444; A61P25/04; A61P29/00; A61P43/00; C12N9/99; C12N15/09

Domestic Patent References:

JPH0559032A

1993-03-09

Foreign References:

WO2001010438A1	2001-02-15
WO2002089787A1	2002-11-14
WO2004089296A2	2004-10-21

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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