Title:
酵素的に分解可能な連結を通じて生物活性因子が組み入れられている合成バイオマテリアル
Document Type and Number:
Japanese Patent JP2008529972
Kind Code:
A
Abstract:
Synthetic biomaterials containing bioactive factors or modified bioactive factors that are covalently bound to the synthetic precursor components and/or biomaterials by an enzymatically degradable linkage are described herein. Further described are methods to covalently bind bioactive factors to synthetic biomaterials by means of enzymatic catalysis, the biomaterials produced therewith and the bioactive factors necessary for practicing these methods. The bioactive factors contain an amino acid sequence which can serve as a substrate domain for cross-linkable enzymes. The enzyme catalyzes the cross-linking reaction between the substrate domain of the bioactive factor and functional groups of the synthetic precursor components capable of forming the biomaterial and/or synthetic biomaterial susceptible to an enzymatically catalyzed cross-linking reaction. The biomaterials described herein may be used for localized delivery of the bioactive factors, for tissue repair and regeneration and in particular for regeneration of soft and hard tissue, such as skin, bone, tendons and cartilage.
Inventors:
Jason, Schense
Cowling, didier
Luttorf, Matthias
Rehore, Anemi
Cowling, didier
Luttorf, Matthias
Rehore, Anemi
Application Number:
JP2007547538A
Publication Date:
August 07, 2008
Filing Date:
December 22, 2005
Export Citation:
Assignee:
Cross Biosurgery Akchen Gesell Shaft
International Classes:
A61K47/48; A61K38/00; A61K38/22; A61K38/27; A61K47/20; A61K47/34; A61K48/00; A61P43/00; C07K17/02
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya