Title:
増殖性疾患の治療のための化合物
Document Type and Number:
Japanese Patent JP2008530240
Kind Code:
A
Abstract:
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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Inventors:
Sung Li Jun
Bolera christopher
Lee Hao
Gian Jun
Chen Show Jun
Keizo Furuya
Takayo Inoue
Do Tsengian
Foray Kevin
Wu Yamin
Tsang Mei
In Waywen
Bolera christopher
Lee Hao
Gian Jun
Chen Show Jun
Keizo Furuya
Takayo Inoue
Do Tsengian
Foray Kevin
Wu Yamin
Tsang Mei
In Waywen
Application Number:
JP2007556341A
Publication Date:
August 07, 2008
Filing Date:
February 16, 2006
Export Citation:
Assignee:
Shinta Pharmaceuticals Corporation
International Classes:
C07D261/08; A61K31/42; A61K31/422; A61P9/00; A61P27/02; A61P35/00; A61P43/00; C07D413/04; C07F9/653
Foreign References:
| WO2004072051A1 | 2004-08-26 | |||
| WO2004026865A1 | 2004-04-01 |
Other References:
JPN6012014239; Ｍａｙａ ＡＢＳ ｅｔ ａｌ: Ｊ Ｍｅｄ Ｃｈｅｍ Ｖｏｌ．４８, 20041231, ｐ．５５６-５６８
JPN6012014240; Ｍａｙａ ＡＢＳ ｅｔ ａｌ: Ｂｉｏｏｒｇ Ｍｅｄ Ｃｈｅｍ Ｖｏｌ．１３, 20050201, ｐ．２０９７-２１０７
JPN6012014240; Ｍａｙａ ＡＢＳ ｅｔ ａｌ: Ｂｉｏｏｒｇ Ｍｅｄ Ｃｈｅｍ Ｖｏｌ．１３, 20050201, ｐ．２０９７-２１０７
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi