Title:
モノクローナル抗体を使用するアルツハイマー病のinvitro診断の方法
Document Type and Number:
Japanese Patent JP2008532984
Kind Code:
A
Abstract:
Method of in-vitro diagnosis of Alzheimer's disease by means of a monoclonal antibody. Said antibody is capable of binding to at least the amino acids 12-16 of ²-amyloid peptide, specifically detecting the neuritic plaques that are characteristic of Alzheimer's disease, without detecting diffuse plaques, which are not indicators of the disease, Among the neuritic plaques, the monoclonal antibody makes it possible to detect a subgroup that differs in the composition of the various isoforms of ²-amyloid peptide that are deposited, which is associated with the stage of progression of the disease. Moreover, the antibody is capable of binding to isoforms of ²-amyloid peptide in biological fluids such as urine. Accordingly, the monoclonal antibody of the invention, the cell lines which produce it and the compositions containing it can be used in the in-vitro diagnosis of Alzheimer's disease and determination of the stage of progression of the disease,
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Inventors:
Mendes, Enrique
Application Number:
JP2008500220A
Publication Date:
August 21, 2008
Filing Date:
March 09, 2006
Export Citation:
Assignee:
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
International Classes:
C07K16/18; C12N5/10; G01N27/62; G01N33/53; G01N33/543; G01N33/577; C12N15/02; C12P21/08
Foreign References:
| WO2004029630A1 | 2004-04-08 | |||
| WO2004029630A1 | 2004-04-08 |
Other References:
JPN6011059140; Ｂｉｏｃｈｅｍｉｓｔｒｙ， １９９５ Ａｕｇ １５， Ｖｏｌ．３４， Ｎｏ．３２， ｐ．１０２７２-１０２７８
JPN6011059141; Ａｍ Ｊ Ｐａｔｈｏｌ．， ２００１ Ｊｕｎ， Ｖｏｌ．１５８， Ｎｏ．６， ｐ．２２０９-２２１８
JPN6011059142; Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ．， １９９５ Ｊｕｎ ３０， Ｖｏｌ．１９３， Ｎｏ．２， ｐ．１０５-１０８
JPN6011059143; ＦＡＳＥＢ Ｊ．， ２００４ Ｎｏｖ， Ｖｏｌ．１８， Ｎｏ．１４， ｐ．１７５５-１７５７
JPN6011059140; Ｂｉｏｃｈｅｍｉｓｔｒｙ， １９９５ Ａｕｇ １５， Ｖｏｌ．３４， Ｎｏ．３２， ｐ．１０２７２-１０２７８
JPN6011059141; Ａｍ Ｊ Ｐａｔｈｏｌ．， ２００１ Ｊｕｎ， Ｖｏｌ．１５８， Ｎｏ．６， ｐ．２２０９-２２１８
JPN6011059142; Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ．， １９９５ Ｊｕｎ ３０， Ｖｏｌ．１９３， Ｎｏ．２， ｐ．１０５-１０８
JPN6011059143; ＦＡＳＥＢ Ｊ．， ２００４ Ｎｏｖ， Ｖｏｌ．１８， Ｎｏ．１４， ｐ．１７５５-１７５７
JPN6011059141; Ａｍ Ｊ Ｐａｔｈｏｌ．， ２００１ Ｊｕｎ， Ｖｏｌ．１５８， Ｎｏ．６， ｐ．２２０９-２２１８
JPN6011059142; Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ．， １９９５ Ｊｕｎ ３０， Ｖｏｌ．１９３， Ｎｏ．２， ｐ．１０５-１０８
JPN6011059143; ＦＡＳＥＢ Ｊ．， ２００４ Ｎｏｖ， Ｖｏｌ．１８， Ｎｏ．１４， ｐ．１７５５-１７５７
JPN6011059140; Ｂｉｏｃｈｅｍｉｓｔｒｙ， １９９５ Ａｕｇ １５， Ｖｏｌ．３４， Ｎｏ．３２， ｐ．１０２７２-１０２７８
JPN6011059141; Ａｍ Ｊ Ｐａｔｈｏｌ．， ２００１ Ｊｕｎ， Ｖｏｌ．１５８， Ｎｏ．６， ｐ．２２０９-２２１８
JPN6011059142; Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ．， １９９５ Ｊｕｎ ３０， Ｖｏｌ．１９３， Ｎｏ．２， ｐ．１０５-１０８
JPN6011059143; ＦＡＳＥＢ Ｊ．， ２００４ Ｎｏｖ， Ｖｏｌ．１８， Ｎｏ．１４， ｐ．１７５５-１７５７
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda