Title:
アセトアミノフェン、ラニチジン、ストリキニーネおよびデナトニウムのpヒトT2R受容体、ならびにヒト苦味調節剤を同定するための関連アッセイ
Document Type and Number:
Japanese Patent JP2008537473
Kind Code:
A
Abstract:
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
Inventors:
Ziao Dong, Lee
Zhu, Hong
Tan, Huizian
Lee, Queen
Zhu, Hong
Tan, Huizian
Lee, Queen
Application Number:
JP2007555113A
Publication Date:
September 18, 2008
Filing Date:
January 06, 2006
Export Citation:
Assignee:
Cenomics Incorporated
International Classes:
C12Q1/02; G01N21/78; G01N33/15; C12N15/09
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya