Title:
反応性蛍光標識試薬としての水溶性フルオロ置換シアニン色素
Document Type and Number:
Japanese Patent JP2008538382
Kind Code:
A
Abstract:
Disclosed are compounds of formula:
wherein:
the groups R 1 , R 11 and R 12 are selected independently from -L-M, -L-P, C 1 -C 6 alkyl and -(CH 2 ) k -SO 3 H, where k is an integer from 1 to 10;
the groups R 3 , R 4 , R 5 and R 6 are selected independently from hydrogen, -L-M, -L-P, -SO 3 H, -SO 2 -CF 3 and
-(CF 2 ) m -F, where m is 0 or an integer from 1 to 4; or R 3 taken in combination with R 4 or R 5 taken in combination with R 6 form a fused aromatic six-membered ring containing carbon atoms and being optionally substituted one or more times by -SO 3 H, -SO 2 -CF 3 or -(CF 2 ) m -F, where m is hereinbefore defined;
L is a linking group having a chain from 1-20 linked atoms selected from the group consisting of carbon, nitrogen, oxygen and sulphur atoms;
M is a target bonding group; and
P is a conjugated component;
provided that:
i) at least one of groups R 1 , R 3 , R 4 , R 5 , R 6 , R 11 and R 12 is -L-M or -L-P;
ii) at least one of groups R 3 , R 4 , R 5 and R 6 comprises fluorine; and
iii) when any one of R 3 , R 4 , R 5 and R 6 is -SO 3 H at least one of groups R 11 and R 12 is selected from -L-M, -L-P and -(CH 2 ) k -SO 3 H.
Inventors:
Cooper, michael edward
Gardner, Nicholas John
Rafton, Peter Gordon
Gardner, Nicholas John
Rafton, Peter Gordon
Application Number:
JP2008507155A
Publication Date:
October 23, 2008
Filing Date:
April 18, 2006
Export Citation:
Assignee:
GE Healthcare UK Limited
International Classes:
C09B23/00; C07D209/12; G01N33/533
Domestic Patent References:
| JPH0783924A | 1995-03-31 | |||
| JP2001288197A | 2001-10-16 | |||
| JP2004510011A | 2004-04-02 | |||
| JPH02255985A | 1990-10-16 |
Foreign References:
| WO2002026891A1 | 2002-04-04 |
Other References:
JPN6012001804; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１５，Ｎｏ．１, 2004, ｐ．７０-７８
JPN6012001805; Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．６，Ｎｏ．６, 2004, ｐ．９０９-９１２
JPN6012001805; Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．６，Ｎｏ．６, 2004, ｐ．９０９-９１２
Attorney, Agent or Firm:
Kenichi Matsumoto
Hirokazu Ogura
Toshihisa Kurokawa
Hirokazu Ogura
Toshihisa Kurokawa