Title:
同系または非同系の細胞、組織または器官を含む、外因性免疫原および内因性免疫原に対する免疫応答を改変するための材料および方法
Document Type and Number:
Japanese Patent JP2008538587
Kind Code:
A
Abstract:
Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity.
Inventors:
Edelman, Elather Earl.
Nugent, Helen Marie
Messe, Heiko
Nugent, Helen Marie
Messe, Heiko
Application Number:
JP2008507993A
Publication Date:
October 30, 2008
Filing Date:
April 21, 2006
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Pervasives Therapeutics, Incorporated
Pervasives Therapeutics, Incorporated
International Classes:
A61K35/12; A61K9/00; A61K9/06; A61K9/08; A61K9/10; A61K39/00; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61L27/00; A61P37/06; C12N5/071
Other References:
JPN6012009056; Ｍｅｔｈｅ Ｈ， ｅｔ ａｌ．: 'Ｍａｔｒｉｘ-ｅｍｂｅｄｄｉｎｇ ａｌｔｅｒｓ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ-ｌｙｍｐｈｏｃｙｔｅ ｉｎｔｅｒａｃｔｉｏｎｓ' Ｔｈｅ ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ． １９， Ｎｏ． ５， Ｓｕｐｐｌ．， Ｐａｒｔ ２, 20050307, ｐ． Ａ１４１２
JPN6012009058; Ｍｅｔｈｅ Ｈ， ｅｔ ａｌ．: 'Ｍａｔｒｉｘ ｅｍｂｅｄｄｉｎｇ ａｌｔｅｒｓ ｔｈｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ａｇａｉｎｓｔ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌｓ ｉｎ ｖｉｔｒｏ ａｎｄ ｉｎ ｖｉｖｏ' Ｃｉｒｃｕｌａｔｉｏｎ Ｖｏｌ． １１０， Ｎｏ． １７， Ｓｕｐｐｌ．, 20041026, ｐ． ５０８
JPN5008004633; Ｎｕｇｅｎｔ ＨＭ， ｅｔ ａｌ．: 'Ｐｅｒｉｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｉｍｐｌａｎｔｓ ｉｎｈｉｂｉｔ ｉｎｔｉｍａｌ ｈｙｐｅｒｐｌａｓｉａ ｉｎ ａ ｍｏｄｅｌ ｏｆ ａｒｔｅｒｉｏｖｅｎｏｕｓ ｆｉｓｔｕｌａｅ：' Ｊｏｕｒｎａｌ ｏｆ Ｖａｓｃｕｌａｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ３９， Ｎｏ． ６, 200212, ｐ． ５２４-５３３
JPN5008004634; Ｎｕｇｅｎｔ ＨＭ， ｅｔ ａｌ．: 'Ｅｎｄｏｔｈｅｌｉａｌ ｉｍｐｌａｎｔｓ ｉｎｈｉｂｉｔ ｉｎｔｉｍａｌ ｈｙｐｅｒｐｌａｓｉａ ａｆｔｅｒ ｐｏｒｃｉｎｅ ａｎｇｉｏｐｌａｓｔｙ' Ｃｉｒｃｕｌａｔｉｏｎ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ８４， Ｎｏ． ４, 19990305, ｐ． ３８４-３９１
JPN5008004635; Ｃｅｎｔｒａ Ｍ， ｅｔ ａｌ．: 'Ｃｕｌｔｕｒｅ ｏｆ ｂｏｖｉｎｅ ｐｕｌｍｏｎａｒｙ ａｒｔｅｒｙ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌｓ ｏｎ Ｇｅｌｆｏａｍ ｂｌｏｃｋｓ' Ｔｈｅ ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ． ６， Ｎｏ． １２, 199209, ｐ． ３１１７-３１２１
JPN6012009059; 伊藤正男ら編: '「免疫原性」' 医学書院医学大辞典 , 20030301, ｐ． ２４０９, 株式会社医学書院
JPN6012009058; Ｍｅｔｈｅ Ｈ， ｅｔ ａｌ．: 'Ｍａｔｒｉｘ ｅｍｂｅｄｄｉｎｇ ａｌｔｅｒｓ ｔｈｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ａｇａｉｎｓｔ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌｓ ｉｎ ｖｉｔｒｏ ａｎｄ ｉｎ ｖｉｖｏ' Ｃｉｒｃｕｌａｔｉｏｎ Ｖｏｌ． １１０， Ｎｏ． １７， Ｓｕｐｐｌ．, 20041026, ｐ． ５０８
JPN5008004633; Ｎｕｇｅｎｔ ＨＭ， ｅｔ ａｌ．: 'Ｐｅｒｉｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｉｍｐｌａｎｔｓ ｉｎｈｉｂｉｔ ｉｎｔｉｍａｌ ｈｙｐｅｒｐｌａｓｉａ ｉｎ ａ ｍｏｄｅｌ ｏｆ ａｒｔｅｒｉｏｖｅｎｏｕｓ ｆｉｓｔｕｌａｅ：' Ｊｏｕｒｎａｌ ｏｆ Ｖａｓｃｕｌａｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ３９， Ｎｏ． ６, 200212, ｐ． ５２４-５３３
JPN5008004634; Ｎｕｇｅｎｔ ＨＭ， ｅｔ ａｌ．: 'Ｅｎｄｏｔｈｅｌｉａｌ ｉｍｐｌａｎｔｓ ｉｎｈｉｂｉｔ ｉｎｔｉｍａｌ ｈｙｐｅｒｐｌａｓｉａ ａｆｔｅｒ ｐｏｒｃｉｎｅ ａｎｇｉｏｐｌａｓｔｙ' Ｃｉｒｃｕｌａｔｉｏｎ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ８４， Ｎｏ． ４, 19990305, ｐ． ３８４-３９１
JPN5008004635; Ｃｅｎｔｒａ Ｍ， ｅｔ ａｌ．: 'Ｃｕｌｔｕｒｅ ｏｆ ｂｏｖｉｎｅ ｐｕｌｍｏｎａｒｙ ａｒｔｅｒｙ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌｓ ｏｎ Ｇｅｌｆｏａｍ ｂｌｏｃｋｓ' Ｔｈｅ ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ． ６， Ｎｏ． １２, 199209, ｐ． ３１１７-３１２１
JPN6012009059; 伊藤正男ら編: '「免疫原性」' 医学書院医学大辞典 , 20030301, ｐ． ２４０９, 株式会社医学書院
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita