Title:
CLEC-2シグナル伝達により止血疾患を治療するための組成物および方法
Document Type and Number:
Japanese Patent JP2008539694
Kind Code:
A
Abstract:
The present invention provides a method for screening compounds to identify therapeutic candidates for treating hemostasis disorders, the method includes the steps of contacting a cell that expresses a CLEC-2 receptor with a test compound and a CLEC-2 receptor ligand, under conditions which, but for the presence of the test compound, permit binding of the CLEC-2 receptor to the CLEC-2 receptor ligand; and detecting if any increase or decrease in an indicator of CLEC-2 receptor activity is observed in comparison to a control; wherein an increase or decrease in the indicator in comparison to the control indicates that the test compound is a candidate for modulating hemostasis.
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Inventors:
Yuuki Ozaki
Katsue Inoue
Watson, Steve Pee.
Katsue Inoue
Watson, Steve Pee.
Application Number:
JP2007549752A
Publication Date:
November 20, 2008
Filing Date:
April 24, 2006
Export Citation:
Assignee:
Yamanashi University
International Classes:
C12Q1/02; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P7/02; A61P9/00; A61P9/10; A61P43/00; C07K16/28; C12N15/09; G01N33/15; G01N33/50
Foreign References:
| WO2002031111A2 | 2002-04-18 |
Attorney, Agent or Firm:
Hideki Ishikawa
Masao Tanaka
Masao Tanaka