Title:
AKAP-PKA相互作用の非ペプチド阻害剤
Document Type and Number:
Japanese Patent JP2008540586
Kind Code:
A
Abstract:
The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
Inventors:
Cruzman, Enno
Rosenthal, Walter
Rademann, Jörg
Christian, frank
Sina Meyer
Rosenthal, Walter
Rademann, Jörg
Christian, frank
Sina Meyer
Application Number:
JP2008511551A
Publication Date:
November 20, 2008
Filing Date:
May 18, 2006
Export Citation:
Assignee:
Forschungsverbund Berlin e.V.
International Classes:
C07C31/137; A61K31/122; A61K31/136; A61K31/15; A61K31/16; A61K31/17; A61K31/175; A61K31/18; A61K31/198; A61K31/221; A61K31/27; A61K31/341; A61K31/352; A61K31/36; A61K31/381; A61K31/40; A61K31/403; A61K31/41; A61K31/415; A61K31/428; A61K31/429; A61K31/437; A61K31/44; A61K31/47; A61K31/472; A61K31/505; A61K31/515; A61K31/53; A61K45/00; A61P3/04; A61P3/10; A61P3/12; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P11/02; A61P11/06; A61P11/16; A61P13/02; A61P15/00; A61P15/10; A61P15/12; A61P17/00; A61P17/10; A61P17/14; A61P19/02; A61P19/04; A61P19/08; A61P19/10; A61P21/00; A61P21/02; A61P25/00; A61P27/02; A61P31/00; A61P31/18; A61P33/00; A61P37/08; C07C50/10; C07C69/157; C07C69/94; C07C211/45; C07C215/76; C07C215/80; C07C225/22; C07C233/05; C07C233/09; C07C245/08; C07C251/08; C07C251/24; C07C335/32; C07K16/00
Domestic Patent References:
| JP2005538930A | 2005-12-22 | |||
| JP2005517675A | 2005-06-16 | |||
| JPS4828486A | 1973-04-14 | |||
| JP2005517675A | 2005-06-16 | |||
| JPS4828486A | 1973-04-14 |
Foreign References:
| US3248426A | 1966-04-26 | |||
| WO2003073999A2 | 2003-09-12 | |||
| US3248426A | 1966-04-26 | |||
| WO2003073999A2 | 2003-09-12 |
Other References:
JPN6012002135; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１２１，Ｎｏ．３６, 1999, ｐ．８１４６-８１５６
JPN6012002136; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７３, 1951, ｐ．４６４-４６５
JPN6012002137; Ｒｕｓｓｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ） Ｖｏｌ．３３，Ｎｏ．７, 1997, ｐ．１０１０-１０１３
JPN6012002138; Ｂｅｒｉｃｈｔｅ ｄｅｒ Ｄｅｕｔｓｃｈｅｎ Ｃｈｅｍｉｓｃｈｅｎ Ｇｅｓｅｌｌｓｃｈａｆｔ Ｖｏｌ．３９, 1907, ｐ．２６３１-２６３８
JPN6012002139; ＳＴＮ Ｉｎｔｅｒｎｔｉｏｎａｌ， ｆｉｌｅ ＣＨＥＭＣＡＴＳ , 20010430
JPN6012002140; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．２５，Ｎｏ．１８, 1976, ｐ．２０１５-２０２４
JPN6012002141; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．４９，Ｎｏ．５, 1976, ｐ．１３６３-１３６５
JPN6012002142; Ａｎａｌ． Ｃｈｅｍ． Ｖｏｌ．２６, 1954, ｐ．１５８９-１５９２
JPN6012002143; Ｇａｚｚｅｔｔａ Ｃｈｉｍｉｃａ Ｉｔａｌｉａｎａ Ｖｏｌ．８５, 1955, ｐ．３７４-３８０
JPN6012002144; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５６，Ｎｏ．３６, 2000, ｐ．６８９９-６９１１
JPN6012002135; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１２１，Ｎｏ．３６, 1999, ｐ．８１４６-８１５６
JPN6012002136; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７３, 1951, ｐ．４６４-４６５
JPN6012002137; Ｒｕｓｓｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ） Ｖｏｌ．３３，Ｎｏ．７, 1997, ｐ．１０１０-１０１３
JPN6012002138; Ｂｅｒｉｃｈｔｅ ｄｅｒ Ｄｅｕｔｓｃｈｅｎ Ｃｈｅｍｉｓｃｈｅｎ Ｇｅｓｅｌｌｓｃｈａｆｔ Ｖｏｌ．３９, 1907, ｐ．２６３１-２６３８
JPN6012002139; ＳＴＮ Ｉｎｔｅｒｎｔｉｏｎａｌ， ｆｉｌｅ ＣＨＥＭＣＡＴＳ , 20010430
JPN6012002140; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．２５，Ｎｏ．１８, 1976, ｐ．２０１５-２０２４
JPN6012002141; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．４９，Ｎｏ．５, 1976, ｐ．１３６３-１３６５
JPN6012002142; Ａｎａｌ． Ｃｈｅｍ． Ｖｏｌ．２６, 1954, ｐ．１５８９-１５９２
JPN6012002143; Ｇａｚｚｅｔｔａ Ｃｈｉｍｉｃａ Ｉｔａｌｉａｎａ Ｖｏｌ．８５, 1955, ｐ．３７４-３８０
JPN6012002144; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５６，Ｎｏ．３６, 2000, ｐ．６８９９-６９１１
JPN6012002136; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７３, 1951, ｐ．４６４-４６５
JPN6012002137; Ｒｕｓｓｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ） Ｖｏｌ．３３，Ｎｏ．７, 1997, ｐ．１０１０-１０１３
JPN6012002138; Ｂｅｒｉｃｈｔｅ ｄｅｒ Ｄｅｕｔｓｃｈｅｎ Ｃｈｅｍｉｓｃｈｅｎ Ｇｅｓｅｌｌｓｃｈａｆｔ Ｖｏｌ．３９, 1907, ｐ．２６３１-２６３８
JPN6012002139; ＳＴＮ Ｉｎｔｅｒｎｔｉｏｎａｌ， ｆｉｌｅ ＣＨＥＭＣＡＴＳ , 20010430
JPN6012002140; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．２５，Ｎｏ．１８, 1976, ｐ．２０１５-２０２４
JPN6012002141; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．４９，Ｎｏ．５, 1976, ｐ．１３６３-１３６５
JPN6012002142; Ａｎａｌ． Ｃｈｅｍ． Ｖｏｌ．２６, 1954, ｐ．１５８９-１５９２
JPN6012002143; Ｇａｚｚｅｔｔａ Ｃｈｉｍｉｃａ Ｉｔａｌｉａｎａ Ｖｏｌ．８５, 1955, ｐ．３７４-３８０
JPN6012002144; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５６，Ｎｏ．３６, 2000, ｐ．６８９９-６９１１
JPN6012002135; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１２１，Ｎｏ．３６, 1999, ｐ．８１４６-８１５６
JPN6012002136; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７３, 1951, ｐ．４６４-４６５
JPN6012002137; Ｒｕｓｓｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ） Ｖｏｌ．３３，Ｎｏ．７, 1997, ｐ．１０１０-１０１３
JPN6012002138; Ｂｅｒｉｃｈｔｅ ｄｅｒ Ｄｅｕｔｓｃｈｅｎ Ｃｈｅｍｉｓｃｈｅｎ Ｇｅｓｅｌｌｓｃｈａｆｔ Ｖｏｌ．３９, 1907, ｐ．２６３１-２６３８
JPN6012002139; ＳＴＮ Ｉｎｔｅｒｎｔｉｏｎａｌ， ｆｉｌｅ ＣＨＥＭＣＡＴＳ , 20010430
JPN6012002140; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．２５，Ｎｏ．１８, 1976, ｐ．２０１５-２０２４
JPN6012002141; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．４９，Ｎｏ．５, 1976, ｐ．１３６３-１３６５
JPN6012002142; Ａｎａｌ． Ｃｈｅｍ． Ｖｏｌ．２６, 1954, ｐ．１５８９-１５９２
JPN6012002143; Ｇａｚｚｅｔｔａ Ｃｈｉｍｉｃａ Ｉｔａｌｉａｎａ Ｖｏｌ．８５, 1955, ｐ．３７４-３８０
JPN6012002144; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５６，Ｎｏ．３６, 2000, ｐ．６８９９-６９１１
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga
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