Title:
4-アミノ-5-フルオロ-3-[6-(4-メチルピペラジン-1イル)-1H-ベンズイミダゾール-2-イル]-1H-キノリン-2-オン乳酸塩の結晶およびその他の形態
Document Type and Number:
Japanese Patent JP2008542289
Kind Code:
A
Abstract:
The present invention relates to non-hydrate crystalline forms of 4-amino- 5-fluoro-3 -[6-(4-methylpiperazin- 1-yl)- 1H-benzimidazol-2-yl] - 1H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts.
More Like This:
Inventors:
Augustus Okuhamefe
Joyce Chow
Lampruna Grapalli
Eric Harwood
David Rickman
Suguang Chu
Xiao Shan
Joyce Chow
Lampruna Grapalli
Eric Harwood
David Rickman
Suguang Chu
Xiao Shan
Application Number:
JP2008513719A
Publication Date:
November 27, 2008
Filing Date:
May 23, 2006
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D401/04; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/496; A61P35/00; A61P35/02
Domestic Patent References:
| JP2008528617A | 2008-07-31 | |||
| JP2007510668A | 2007-04-26 | |||
| JP2007523185A | 2007-08-16 |
Foreign References:
| WO2004043389A2 | 2004-05-27 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi