Title:
N末端修飾GLP-1受容体モジュレーター
Document Type and Number:
Japanese Patent JP2008542292
Kind Code:
A
Abstract:
The subject matter described herein provides novel human glucagon-like peptide-1 (GLP-1) receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. The described compounds include chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The disclosed and claimed peptides show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes.
Inventors:
William Earl Ewing
Claudio Mappelli
Douglas James Leixinger
Bin Gee Lee
Richard B. Sarsky
Yehen Chu
Claudio Mappelli
Douglas James Leixinger
Bin Gee Lee
Richard B. Sarsky
Yehen Chu
Application Number:
JP2008513732A
Publication Date:
November 27, 2008
Filing Date:
May 26, 2006
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07K7/06; A61K38/00; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P17/02; A61P25/00; A61P27/02; A61P43/00
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa