Title:
高度に弱毒化されたポックスウイルス株、その生産方法および防護免疫誘導剤としての使用またはベクターワクチンを生産するための使用
Document Type and Number:
Japanese Patent JP2008546377
Kind Code:
A
Abstract:
The present invention relates to highly attenuated animal smallpox viral strains and to the use thereof as paramunity inducers or for producing vector vaccines. As a result of the high attenuation process, the claimed animal smallpox strains lose their virulent and immunising properties. The invention also relates to a method for producing such highly attenuated pox virus strains and the use thereof for inducing paramunity, i.e. for activating the non-specific immune system in mammals and humans or for producing vector vaccines for specific immunisation with the positive side-effect of paramunisation. The claimed highly attenuated animal smallpox viruses are thus suitable for preventing and treating diseases associated with an immune deficiency. Preferred embodiments relate to highly attenuated orthopox-(e.g. camel smallpox viruses), leporipox-(e.g. myxoma viruses), avipox-, parapox- and other orthopox viral strains, such as MVA, which have excellent paramunisation properties and in which the immunising properties have been lost.
Inventors:
Maia, Anton
Application Number:
JP2008516238A
Publication Date:
December 25, 2008
Filing Date:
June 16, 2006
Export Citation:
Assignee:
Maia, Anton
International Classes:
C12N7/00; A61K31/711; A61K35/76; A61K39/275; A61K48/00; A61P1/16; A61P17/00; A61P31/00; A61P31/04; A61P31/12; A61P31/16; A61P35/00; A61P37/00; A61P37/04; A61P37/06; C12N7/04; C12N15/09
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga