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Title:
スフィンゴシンキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2008546714
Kind Code:
A
Inventors:
チャールズ・ディ・スミス
ケビン・ジェイ・フレンチ
チュアン・ヤン
Application Number:
JP2008517187A
Publication Date:
December 25, 2008
Filing Date:
June 15, 2006
Export Citation:
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Assignee:
アポジー・バイオテクノロジー・コーポレイション
Apogee Biotechnology Corporation
International Classes:
C07C49/567; A61K31/131; A61K31/135; A61K31/136; A61K31/16; A61K31/165; A61K31/275; A61K31/36; A61K31/40; A61K31/403; A61K31/404; A61K31/4164; A61K31/421; A61K31/426; A61K31/428; A61K31/4409; A61K31/4468; A61K31/52; A61K31/5375; A61P1/02; A61P1/04; A61P9/00; A61P9/02; A61P9/10; A61P11/06; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C49/573; C07C61/125; C07C61/15; C07C69/716; C07C231/02; C07C233/58; C07C233/59; C07C233/60; C07C233/62; C07C233/63; C07C255/30; C07C255/56; C07C317/32; C07C321/14; C07D207/09; C07D209/08; C07D209/88; C07D211/58; C07D213/40; C07D233/61; C07D263/58; C07D277/20; C07D277/44; C07D277/82; C07D295/12; C07D317/58; C07D473/34
Domestic Patent References:
JPH07506588A1995-07-20
JP2001524468A2001-12-04
JPS4857939A1973-08-14
JPH04330947A1992-11-18
JP2001354618A2001-12-25
JPH04322743A1992-11-12
JPH04202143A1992-07-22
JPS6097053A1985-05-30
JPS5671075A1981-06-13
JP2008518903A2008-06-05
JPS5671075A1981-06-13
JP2008518903A2008-06-05
JPH07506588A1995-07-20
JP2001524468A2001-12-04
JPS4857939A1973-08-14
JPH04330947A1992-11-18
JP2001354618A2001-12-25
JPH04322743A1992-11-12
JPH04202143A1992-07-22
JPS6097053A1985-05-30
Foreign References:
WO2004089415A22004-10-21
US20040116479A12004-06-17
US4349552A1982-09-14
US6649600B12003-11-18
US3657273A1972-04-18
US4053509A1977-10-11
SU451691A11974-11-30
WO2004089470A22004-10-21
US3663565A1972-05-16
WO2004089470A22004-10-21
US3663565A1972-05-16
WO2004089415A22004-10-21
US20040116479A12004-06-17
US4349552A1982-09-14
US6649600B12003-11-18
US3657273A1972-04-18
US4053509A1977-10-11
SU451691A11974-11-30
Other References:
JPN5008008877; EL-SHERBENY M A: MEDICINAL CHEMISTRY RESEARCH V11 N2, 2002, P74-86
JPN5008008881; DANILENKO G N: PHARMACEUTICAL CHEMISTRY JOURNAL V7 N10, 1973, P621-622
JPN5008008879; MAKAROVA, N.V.: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY V33 N8, 1997, P1252
JPN6012014442; Kozlov, N. G.; Valimae, T.: 'Reductive amination of 1-acetyladamantane with nitriles' Zhurnal Obshchei Khimii 55(3), 1985, 609-13
JPN5008008890; FYTAS G: IL FARMACO V49 N10, 1994, P641-647, SOCIETA CHIMICA ITALIANA
JPN6012014443; STEPANOV, F. N, et al.: 'Adamantane and its derivatives.  XXV.  Reaction of bromomethyl ketones of adamantanes with formamide' ZHURNAL ORGANICHESKOI KHIMII 6(6), 1970, 1195-1198
JPN6012014444; SHVEKHGEIMER, G. A. et al.: 'Synthesis and properties of azoles and their derivatives.  XXX.  Synthesis of heterocyclic compounds' KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII (12), 1976, 1654-1657
JPN5008008896; KONTONASSIOS D: JOURNAL OF MEDICINAL CHEMISTRY V12 N1, 196901, P170-172
JPN6012014446; NO, B. I. et al.: 'Synthesis of N,N'-diphenyl-1,3-adamantanebis(carboximid oyl chloride) and adamantanebis(carboximidat' RUSSIAN JOURNAL OF GENERAL CHEMISTRY (TRANSLATION OF ZHURNAL OBSHCHEI KHIMII) 69(5), 1999, 843-844
JPN6012014445; Chan, Ferdinand C. Y.; Potter, Gerard A.; Barrie, S. Elaine; Haynes,     Benjamin P.; Rowlands, Mart: '3- And 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human     Cytochrome P45017alpha (17alpha-Hydr' Journal of Medicinal Chemistry 39(17), 1996, 3319-3323
JPN5008008882; SAFONOVA O A: PHARMACEUTICAL CHEMISTRY JOURNAL V23 N9, 198909, P760-765, CONSULTANTS BUREAU
JPN6012014441; Danilenko, G. I.; Palii, G. K.; Mokhort, N. A.; Baklan, V. F.: 'Bacteriostatic effect of adamantanecarboxylic acids' Fiziologicheski Aktivnye Veshchestva (1966-1992) 7, 1975, 144-7
JPN5008008884; HANDA, INDRA: JOURNAL OF CHEMICAL AND ENGINEERING DATA V29 N2, 1984, P223-225
JPN5008008888; POZDNYAKOV, V.V.: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY V37 N9, 2001, P1228-1231
JPN5008008882; SAFONOVA O A: PHARMACEUTICAL CHEMISTRY JOURNAL V23 N9, 198909, P760-765, CONSULTANTS BUREAU
JPN6012014441; Danilenko, G. I.; Palii, G. K.; Mokhort, N. A.; Baklan, V. F.: 'Bacteriostatic effect of adamantanecarboxylic acids' Fiziologicheski Aktivnye Veshchestva (1966-1992) 7, 1975, 144-7
JPN5008008884; HANDA, INDRA: JOURNAL OF CHEMICAL AND ENGINEERING DATA V29 N2, 1984, P223-225
JPN5008008888; POZDNYAKOV, V.V.: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY V37 N9, 2001, P1228-1231
JPN5008008877; EL-SHERBENY M A: MEDICINAL CHEMISTRY RESEARCH V11 N2, 2002, P74-86
JPN5008008881; DANILENKO G N: PHARMACEUTICAL CHEMISTRY JOURNAL V7 N10, 1973, P621-622
JPN5008008879; MAKAROVA, N.V.: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY V33 N8, 1997, P1252
JPN6012014442; Kozlov, N. G.; Valimae, T.: 'Reductive amination of 1-acetyladamantane with nitriles' Zhurnal Obshchei Khimii 55(3), 1985, 609-13
JPN5008008890; FYTAS G: IL FARMACO V49 N10, 1994, P641-647, SOCIETA CHIMICA ITALIANA
JPN6012014443; STEPANOV, F. N, et al.: 'Adamantane and its derivatives.  XXV.  Reaction of bromomethyl ketones of adamantanes with formamide' ZHURNAL ORGANICHESKOI KHIMII 6(6), 1970, 1195-1198
JPN6012014444; SHVEKHGEIMER, G. A. et al.: 'Synthesis and properties of azoles and their derivatives.  XXX.  Synthesis of heterocyclic compounds' KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII (12), 1976, 1654-1657
JPN5008008896; KONTONASSIOS D: JOURNAL OF MEDICINAL CHEMISTRY V12 N1, 196901, P170-172
JPN6012014446; NO, B. I. et al.: 'Synthesis of N,N'-diphenyl-1,3-adamantanebis(carboximid oyl chloride) and adamantanebis(carboximidat' RUSSIAN JOURNAL OF GENERAL CHEMISTRY (TRANSLATION OF ZHURNAL OBSHCHEI KHIMII) 69(5), 1999, 843-844
JPN6012014445; Chan, Ferdinand C. Y.; Potter, Gerard A.; Barrie, S. Elaine; Haynes,     Benjamin P.; Rowlands, Mart: '3- And 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human     Cytochrome P45017alpha (17alpha-Hydr' Journal of Medicinal Chemistry 39(17), 1996, 3319-3323
Attorney, Agent or Firm:
田村 恭生
鮫島 睦
齋藤 みの里
品川 永敏