Title:
抗GFRα3抗体
Document Type and Number:
Japanese Patent JP2008546716
Kind Code:
A
Abstract:
Antibodies and antibody fragments that bind to the receptor GFRalpha3 and inhibit formation of a Neublastin-GFRalpha3-Ret ternary complex are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit phosphorylation of Ret in a cell and treat disorders and in a subject.
Inventors:
Wally, Dane S.
Sir, Dyna Wen-E
Seamans, Catherine W.
Sir, Dyna Wen-E
Seamans, Catherine W.
Application Number:
JP2008517215A
Publication Date:
December 25, 2008
Filing Date:
June 16, 2006
Export Citation:
Assignee:
Biogen Idec MA Inc.
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/02; C12N15/09; C12P21/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita