Title:
抗炎症性アリールニトリル化合物
Document Type and Number:
Japanese Patent JP2008546843
Kind Code:
A
Abstract:
Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
Inventors:
Puhilippe Bergeron
Kiaoki Kuhen
Kiaofui Du
Jeff Frey Daygunan
Jason A. Duquette
Daring Gustine
Julio Sea. Medina
Jeff Frey Tee. Miharik
Georg Earl. Dong Dong
Kiaoki Kuhen
Kiaofui Du
Jeff Frey Daygunan
Jason A. Duquette
Daring Gustine
Julio Sea. Medina
Jeff Frey Tee. Miharik
Georg Earl. Dong Dong
Application Number:
JP2008519499A
Publication Date:
December 25, 2008
Filing Date:
June 26, 2006
Export Citation:
Assignee:
Amgen Incorporated
International Classes:
C07D233/64; A61K31/4184; A61K31/429; A61K31/437; A61K31/4439; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K45/00; A61P1/00; A61P1/16; A61P3/10; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/06; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P37/00; A61P37/08; A61P43/00; C07D235/14; C07D239/26; C07D239/36; C07D401/04; C07D409/12; C07D471/04; C07D487/04; C07D495/04; C07D513/04
Domestic Patent References:
| JP2004536796A | 2004-12-09 | |||
| JP2003508388A | 2003-03-04 |
Foreign References:
| WO2006004915A1 | 2006-01-12 | |||
| WO2006004925A1 | 2006-01-12 | |||
| WO2004075863A2 | 2004-09-10 |
Attorney, Agent or Firm:
Toru Ishikawa