Title:
肥満、インスリン抵抗性障害およびミトコンドリア関連障害を処置または予防するための方法および関連する組成物
Document Type and Number:
Japanese Patent JP2009500357
Kind Code:
A
Abstract:
Provided herein are methods and compositions for treating or preventing metabolic disorders, such as obesity and diabetes. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin, or an inhibitory compound, such as nicotinamide.
Inventors:
Milbern, michael
Milne, Jill
Orwell, Johann
Aargman, Carmen
Lagoges, Marie
Dip, michel
Milne, Jill
Orwell, Johann
Aargman, Carmen
Lagoges, Marie
Dip, michel
Application Number:
JP2008519734A
Publication Date:
January 08, 2009
Filing Date:
July 07, 2006
Export Citation:
Assignee:
Sir Tris Pharmaceuticals, Inc.
International Classes:
A61K31/05; A23L1/30; A61K31/122; A61K31/205; A61K31/352; A61K31/355; A61K31/455; A61K31/51; A61K31/519; A61K31/525; A61K31/573; A61K31/706; A61K33/24; A61K45/00; A61K45/06; A61P3/02; A61P3/04; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P13/02; A61P13/12; A61P15/06; A61P15/08; A61P19/02; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P29/02; A61P35/00; A61P35/02; A61P35/04; A61P39/06; A61P43/00
Domestic Patent References:
| JP2006528950A | 2006-12-28 | |||
| JP2001072583A | 2001-03-21 | |||
| JP2007530417A | 2007-11-01 |
Foreign References:
| WO2004105517A1 | 2004-12-09 | |||
| WO2005002672A2 | 2005-01-13 |
Other References:
JPN6012021073; ＤＥＮＧ，Ｊ． ｅｔ ａｌ: 'Ａｎｔｉ-ｄｉａｂｅｔｉｃ ａｃｔｉｖｉｔｙ ｏｆ ｒｅｓｖｅｒａｔｒｏｌ， ａ ｎａｔｕｒａｌ ａｎｔｉｏｘｉｄａｎｔ ｄｅｒｉｖｅｄ ｆｒｏｍ ｇｒａｐｅｓ' ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．４, 200503, ｐ．Ａ６３４
JPN6012021076; ＳＵ，Ｈ． ｅｔ ａｌ: 'Ｒｅｓｖｅｒａｔｒｏｌ ｐｏｓｓｅｓｓｅｓ ｈｙｐｏｇｌｙｃｅｍｉｃ ｅｆｆｅｃｔ ｉｎ ＳＴＺ-ｉｎｄｕｃｅｄ ＩＤＤＭ ｒａｔｓ' ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．５, 200503, ｐ．Ａ１６８１-Ａ１６８２
JPN6012021077; ＢＯＲＲＡ，Ｍ．Ｔ． ｅｔ ａｌ: 'Ｍｅｃｈａｎｉｓｍ ｏｆ ｈｕｍａｎ ＳＩＲＴ１ ａｃｔｉｖａｔｉｏｎ ｂｙ ｒｅｓｖｅｒａｔｒｏｌ' Ｊ Ｂｉｏｌ Ｃｈｅｍ Ｖｏｌ．２８０， Ｎｏ．１７, 2005, ｐ．１７１８７-９５
JPN6012021079; 'Ｎｕｔｒｉｅｎｔ ｃｏｎｔｒｏｌ ｏｆ ｇｌｕｃｏｓｅ ｈｏｍｅｏｓｔａｓｉｓ ｔｈｒｏｕｇｈ ａ ｃｏｍｐｌｅｘ ｏｆ ＰＧＣ-１ａｌｐｈａ ａｎｄ ＳＩＲＴ１' Ｎａｔｕｒｅ Ｖｏｌ．４３４， Ｎｏ．７０２９, 2005, ｐ．１１３-８
JPN6012021081; ＢＩＥＧＡＮＯＷＳＫＩ，Ｐ． ｅｔ ａｌ: 'Ｄｉｓｃｏｖｅｒｉｅｓ ｏｆ ｎｉｃｏｔｉｎａｍｉｄｅ ｒｉｂｏｓｉｄｅ ａｓ ａ ｎｕｔｒｉｅｎｔ ａｎｄ ｃｏｎｓｅｒｖｅｄ ＮＲＫ ｇｅｎｅｓ ｅｓｔａｂｌｉｓｈ ａ Ｐｒｅｉｓｓ-Ｈａｎｄｌｅ' Ｃｅｌｌ Ｖｏｌ．１１７， Ｎｏ．４, 2004, ｐ．４９５-５０２
JPN6012021083; ＲＥＩＤ，Ｍ．Ｂ． ｅｔ ａｌ: 'Ｒｅａｃｔｉｖｅ ｏｘｙｇｅｎ ｉｎ ｓｋｅｌｅｔａｌ ｍｕｓｃｌｅ． Ｉ． Ｉｎｔｒａｃｅｌｌｕｌａｒ ｏｘｉｄａｎｔ ｋｉｎｅｔｉｃｓ ａｎｄ ｆａｔｉｇｕｅ ｉｎ ｖｉｔｒｏ' Ｊ Ａｐｐｌ Ｐｈｙｓｉｏｌ Ｖｏｌ．７３， Ｎｏ．５, 1992, ｐ．１７９７-８０４
JPN6012021076; ＳＵ，Ｈ． ｅｔ ａｌ: 'Ｒｅｓｖｅｒａｔｒｏｌ ｐｏｓｓｅｓｓｅｓ ｈｙｐｏｇｌｙｃｅｍｉｃ ｅｆｆｅｃｔ ｉｎ ＳＴＺ-ｉｎｄｕｃｅｄ ＩＤＤＭ ｒａｔｓ' ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．５, 200503, ｐ．Ａ１６８１-Ａ１６８２
JPN6012021077; ＢＯＲＲＡ，Ｍ．Ｔ． ｅｔ ａｌ: 'Ｍｅｃｈａｎｉｓｍ ｏｆ ｈｕｍａｎ ＳＩＲＴ１ ａｃｔｉｖａｔｉｏｎ ｂｙ ｒｅｓｖｅｒａｔｒｏｌ' Ｊ Ｂｉｏｌ Ｃｈｅｍ Ｖｏｌ．２８０， Ｎｏ．１７, 2005, ｐ．１７１８７-９５
JPN6012021079; 'Ｎｕｔｒｉｅｎｔ ｃｏｎｔｒｏｌ ｏｆ ｇｌｕｃｏｓｅ ｈｏｍｅｏｓｔａｓｉｓ ｔｈｒｏｕｇｈ ａ ｃｏｍｐｌｅｘ ｏｆ ＰＧＣ-１ａｌｐｈａ ａｎｄ ＳＩＲＴ１' Ｎａｔｕｒｅ Ｖｏｌ．４３４， Ｎｏ．７０２９, 2005, ｐ．１１３-８
JPN6012021081; ＢＩＥＧＡＮＯＷＳＫＩ，Ｐ． ｅｔ ａｌ: 'Ｄｉｓｃｏｖｅｒｉｅｓ ｏｆ ｎｉｃｏｔｉｎａｍｉｄｅ ｒｉｂｏｓｉｄｅ ａｓ ａ ｎｕｔｒｉｅｎｔ ａｎｄ ｃｏｎｓｅｒｖｅｄ ＮＲＫ ｇｅｎｅｓ ｅｓｔａｂｌｉｓｈ ａ Ｐｒｅｉｓｓ-Ｈａｎｄｌｅ' Ｃｅｌｌ Ｖｏｌ．１１７， Ｎｏ．４, 2004, ｐ．４９５-５０２
JPN6012021083; ＲＥＩＤ，Ｍ．Ｂ． ｅｔ ａｌ: 'Ｒｅａｃｔｉｖｅ ｏｘｙｇｅｎ ｉｎ ｓｋｅｌｅｔａｌ ｍｕｓｃｌｅ． Ｉ． Ｉｎｔｒａｃｅｌｌｕｌａｒ ｏｘｉｄａｎｔ ｋｉｎｅｔｉｃｓ ａｎｄ ｆａｔｉｇｕｅ ｉｎ ｖｉｔｒｏ' Ｊ Ａｐｐｌ Ｐｈｙｓｉｏｌ Ｖｏｌ．７３， Ｎｏ．５, 1992, ｐ．１７９７-８０４
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita