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Patent Searching and Data


Title:
プロポフオールを含む透明な薬学的水性マイクロエマルジョン及び製造方法
Document Type and Number:
Japanese Patent JP2009500359
Kind Code:
A
Abstract:
The present invention concerns a clear pharmaceutical aqueous emulsion composition which comprises Propofol and a surfactant system and which is particularly usable for a safe administration through intravenous injection. A composition according to the invention is characterized in that the surfactant system comprises in combination at least one pharmaceutically acceptable monovalent metal salt of a fatty acid having from 5 to 23 carbon atoms, and at least one polyethylene glycol hydroxystearate. This combination allows to use a mass ratio (w/w) surfactant system/Propofol which is less than 4 and preferably less than or equal to 2.8, while obtaining such a clear composition.

Inventors:
Pougnas Jean-Ruck
Browsaud Olivier
Calvette Nicholas
Contat Sophie
Application Number:
JP2008519800A
Publication Date:
January 08, 2009
Filing Date:
July 08, 2005
Export Citation:
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Assignee:
Physica Pharma
International Classes:
A61K31/05; A61K9/107; A61K47/10; A61K47/12; A61K47/14; A61K47/16; A61K47/34; A61P23/00
Foreign References:
WO2004032910A12004-04-22
WO2005058291A12005-06-30
Attorney, Agent or Firm:
Eiji Saegusa
Kenji Saito
Mutsuko Nakano
Masahito Hayashi