Title:
システインプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2009500376
Kind Code:
A
Abstract:
A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is -C1-C5 straight or branched chain, optionally fluorinated, alkyl or -CH2CR5C3-C4-Cycloalkyl; R4 is H; R5 is H, C1-C2 alkyl, C1-C2 haloalkyl, hydroxyl, OC1-C2alkyl, fluoro; R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or heterocycle wherein the or each ring has 4, 5 or 6 ring atoms and 0 to 3 hetero atoms selected from S, O and N; Rb is haloalkyl; Rc is H or C1-C4 alkyl; and pharmaceutically acceptable salts, hydrates or N-oxides thereof have utility in the treatment of disorders characterised by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
Inventors:
David Tickle
Kevin Parkes
Matt Tozer
Ursula Gravoska
Kevin Parkes
Matt Tozer
Ursula Gravoska
Application Number:
JP2008519939A
Publication Date:
January 08, 2009
Filing Date:
July 06, 2006
Export Citation:
Assignee:
MEDIVIR AKTIEBOLAG
International Classes:
C07D493/04; A61K31/407; A61K31/4439; A61K31/496; A61P1/02; A61P19/02; A61P19/08; A61P19/10; A61P25/04; A61P29/00; A61P35/00; A61P43/00; C07D471/04
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa