Title:
改良されたアミノ酸及び代謝産物生合成
Document Type and Number:
Japanese Patent JP2009501512
Kind Code:
A
Abstract:
Bacterial strains that are engineered to increase the production of amino acids, including aspartate-derived amino acids (e.g., methionine, lysine, threonine, isoleucine, and S-adenosylmethionine (S-AM)) and cysteine, and related metabolites are described. The strains can be genetically engineered to harbor one or more nucleic acid molecules (e.g., recombinant nucleic acid molecules) encoding a polypeptide (e.g., a polypeptide that is heterologous or homologous to the host cell) and/or they may be engineered to increase or decrease expression and/or activity of polypeptides (e.g., by mutation of endogenous nucleic acid sequences).
Inventors:
Madden, Kevin Ti.
Wall Bridge, Michael Jay.
Jorgay, Peter S.
Doten, reed
Wall Bridge, Michael Jay.
Jorgay, Peter S.
Doten, reed
Application Number:
JP2008517198A
Publication Date:
January 22, 2009
Filing Date:
June 19, 2006
Export Citation:
Assignee:
IRONWOOD PHARMACEUTICALS,INC.
International Classes:
C12N1/21; C12N15/09; C12P13/04; C12P13/08; C12P13/12; C12R1/15
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Atsushi Honda
Miho Ikegami
Makoto Onda
Atsushi Honda
Miho Ikegami