Title:
エソメプラゾール及びその塩の製造方法
Document Type and Number:
Japanese Patent JP2009502906
Kind Code:
A
Abstract:
Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(−)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(−)-binol, and removing the (S)-(−)-binol moiety from the crystallized inclusion complex.
Inventors:
Hatehi
Kim Won Jung
Ohisuku
Park Chang Hee
Je Jeol
Kim Han Kyung
Seohyun
Kim Won Jung
Ohisuku
Park Chang Hee
Je Jeol
Kim Han Kyung
Seohyun
Application Number:
JP2008523792A
Publication Date:
January 29, 2009
Filing Date:
July 11, 2006
Export Citation:
Assignee:
Hammi Farm. Seeo., LDT.
International Classes:
C07D401/12; A61K31/4439; A61P1/04
Attorney, Agent or Firm:
Hiroshi Maeda
Hiroshi Takeuchi
Takahisa Shimada
Yuji Takeuchi
Katsumi Imae
Atsushi Fujita
Kazunari Ninomiya
Tomoo Harada
Iseki Katsumori
Seki Kei
Yasuya Sugiura
Hiroshi Takeuchi
Takahisa Shimada
Yuji Takeuchi
Katsumi Imae
Atsushi Fujita
Kazunari Ninomiya
Tomoo Harada
Iseki Katsumori
Seki Kei
Yasuya Sugiura