Title:
治療に対する応答を予測するための方法
Document Type and Number:
Japanese Patent JP2009504142
Kind Code:
A
Abstract:
The invention is related to a method of predicting the response to a treatment with a HER dimerization inhibitor in a patient comprising the steps of assessing a marker gene or a combination of marker genes selected from the group consisting of an epidermal growth factor, a transforming growth factor alpha and a HER2 marker gene or a combination of marker genes comprising an amphiregulin marker gene and a marker gene selected from an epidermal growth factor, a transforming growth factor alpha and a HER2 marker gene in a biological sample from the patient and predicting the response to the treatment with the HER dimerization inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.
Inventors:
Mex, Joachim
Strauss, Andreas
Tsugumeier, Gerhard
Strauss, Andreas
Tsugumeier, Gerhard
Application Number:
JP2008525399A
Publication Date:
February 05, 2009
Filing Date:
May 24, 2006
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12Q1/68; A61K39/395; A61K45/00; A61P11/00; A61P13/08; A61P15/00; A61P35/00; A61P43/00; C12N15/09; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JP2005519624A | 2005-07-07 |
Foreign References:
| WO2006063042A2 | 2006-06-15 | |||
| WO2004008099A2 | 2004-01-22 | |||
| WO2004053497A2 | 2004-06-24 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Tatsunori Ikeda
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Tatsunori Ikeda