Title:
腫瘍の診断及び治療のための標的としてのプレキシンD1
Document Type and Number:
Japanese Patent JP2009506985
Kind Code:
A
Abstract:
The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexin D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.
Inventors:
Rendels, Wilhelm Petrus Johannes
Rhodeink, illus
Raats, Joseph Maria Hendrick
Rhodeink, illus
Raats, Joseph Maria Hendrick
Application Number:
JP2008521907A
Publication Date:
February 19, 2009
Filing Date:
July 20, 2006
Export Citation:
Assignee:
Stay hitting casolique universitite
International Classes:
A61K45/00; A61K31/7088; A61K31/713; A61K38/00; A61K39/395; A61P9/10; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07K14/71; C07K16/28; C12N15/09; G01N33/574
Foreign References:
| WO2001014420A2 | 2001-03-01 | |||
| WO2005056791A1 | 2005-06-23 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura