Title:
GABAAα5逆アゴニストとしてのイソオキサゾロ誘導体
Document Type and Number:
Japanese Patent JP2009508905
Kind Code:
A
Abstract:
The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula wherein R1, R2, R3, R4, and R5, and m are as defined herein and with their pharmaceutically acceptable acid addition salts. This class of compounds have high affinity and selectivity for GABA A alpha5 receptor binding sites and therefore may be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
Inventors:
Buttelmann, Bernd
Han, Bo
Kunst, Henner
Nettecofen, Matthias Heinrich
Thomas, Andrew William
Han, Bo
Kunst, Henner
Nettecofen, Matthias Heinrich
Thomas, Andrew William
Application Number:
JP2008531661A
Publication Date:
March 05, 2009
Filing Date:
September 07, 2006
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D413/06; A61K31/422; A61K31/4439; A61K31/454; A61K31/46; A61K31/4725; A61K31/497; A61K31/5377; A61K31/541; A61P25/28; A61P43/00; C07D413/14; C07D451/06; C07D487/04
Domestic Patent References:
| JP2004509119A | 2004-03-25 |
Foreign References:
| WO2006001750A1 | 2006-01-05 | |||
| WO2005056004A1 | 2005-06-23 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito