コルチコトロピン放出因子(CRF)受容体拮抗薬として有用なピラゾロ[1,5-α]ピリミジニル誘導体

Title:

コルチコトロピン放出因子(CRF)受容体拮抗薬として有用なピラゾロ[1,5-α]ピリミジニル誘導体

Document Type and Number:

Japanese Patent JP2009510004

Kind Code:

A

Abstract:

CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals. The CRF receptor antagonists of this invention have the following structure: (I); and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2a, R2b, Y, Het, n, o, R6, Ar and R7 are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

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Inventors:

Frank Hosner

Application Number:

JP2008532687A

Publication Date:

March 12, 2009

Filing Date:

September 28, 2006

Export Citation:

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Assignee:

SB Pharmco Puerto Rico Inc

International Classes:

C07D487/04; A61K31/519; A61P1/04; A61P25/22; A61P25/24; A61P43/00

Foreign References:

WO2006044958A1	2006-04-27
WO2006044958A1	2006-04-27

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita

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