Title:
[3+2]アジド-アルキン環付加を使用するターゲットにされたイメージング及び/又は治療
Document Type and Number:
Japanese Patent JP2009512641
Kind Code:
A
Abstract:
The use of a selective chemical and bioorthogonal reaction providing a covalent ligation such as the [3+2] cycloaddition, in targeted molecular imaging and therapy is presented, more specifically with interesting applications for pre-targeted imaging or therapy. Current pre-targeted imaging is hampered by the fact that it relies solely on natural/biological targeting constructs (biotin/streptavidin). Size considerations and limitations associated with their endogenous nature severely limit the number of applications. The present invention describes how the use of an abiotic, bio-orthogonal reaction which forms a stable adduct under physiological conditions, by way of a small or undetectable bond, can overcome these limitations.
Inventors:
Lobby, marques
Grühl, Holger
Grühl, Holger
Application Number:
JP2008534122A
Publication Date:
March 26, 2009
Filing Date:
September 29, 2006
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
A61B5/055; A61K51/00; A61K47/48; G01T1/161
Attorney, Agent or Firm:
Tadahiko Ito
Shinsuke Onuki
Tadashige Ito
Shinsuke Onuki
Tadashige Ito