Title:
生理活性物質-血液蛋白質複合体及びこれを利用する生理活性物質の安定化方法
Document Type and Number:
Japanese Patent JP2009513627
Kind Code:
A
Abstract:
This invention relates to a technology of modifying low-molecular-weight bioactive substances with short in vivo half-life and low stability in order to achieve a stable and efficient in vivo delivery thereof. More specifically, the present invention relates to a stable bioactive substance-blood protein conjugate, wherein a low-molecular-weight bioactive substance is ex vivo conjugated with a specific functional group on a blood protein through a reactive group, the low-molecular-weight bioactive substance is available as a drug for treatment and prevention in mammals including human and selected from the group consisting of a natural substance; and a method of a stable and efficient in vivo delivery of the low-molecular-weight bioactive substance based on the use of the bioactive substance-blood protein conjugate.
Inventors:
Park, John-Ill
Song, Min-Gyu
Kim, Hyun-Jack
Rim, Chae Jin
Kang, John-Phil
Choi, Wheel
Song, Min-Gyu
Kim, Hyun-Jack
Rim, Chae Jin
Kang, John-Phil
Choi, Wheel
Application Number:
JP2008537604A
Publication Date:
April 02, 2009
Filing Date:
October 27, 2006
Export Citation:
Assignee:
Peptron Company Limited
International Classes:
A61K47/48; A61K38/00; A61K38/22; A61K47/20; A61K47/22; A61K47/42; A61P3/10; A61P5/48; A61P15/00; A61P35/00; A61P43/00; C07K14/575; C07K14/765; C07K19/00
Domestic Patent References:
| JPH01500901A | 1989-03-30 |
Foreign References:
| WO2003103572A2 | 2003-12-18 |
Other References:
JPN6012019815; Ｊ．ＡＭ．ＣＨＥＭ．ＳＯＣ． Ｖｏｌ．１２６, 2004, ｐ．１５３７２-１５３７３
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki