Title:
HIVインテグラーゼインヒビター
Document Type and Number:
Japanese Patent JP2009513640
Kind Code:
A
Abstract:
Substituted hydroxytetrahydropyrrolopyrazinone and substituted hydroxytetrahydro-pyrazolopyrazinone compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein R1, R2, R3, R4; R5, X, ring A, and Q are as defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
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Inventors:
Wye, Jiyoung S
Williams, Peter Day
Lyle, Terry A
Williams, Peter Day
Lyle, Terry A
Application Number:
JP2008537840A
Publication Date:
April 02, 2009
Filing Date:
October 23, 2006
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D487/04; A61K31/4985; A61K45/00; A61P31/18; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura