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Title:
親水性ベヒクルに基づく二重制御された放出マトリクスシステム
Document Type and Number:
Japanese Patent JP2009513669
Kind Code:
A
Abstract:
A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a hydrophilic vehicle. The primary rate controlling barrier can further comprise one or more solvents which are miscible with the hydrophilic vehicle. The secondary rate controlling barrier includes a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle. The presence of the hydrogel-forming polymeric material makes extraction of the drug from the dosage form more difficult. This feature could be beneficial in preventing or minimizing the misuse of dosage forms which contain drugs which are prone to abuse.

Inventors:
Skull, Karnakal
Application Number:
JP2008538048A
Publication Date:
April 02, 2009
Filing Date:
October 26, 2006
Export Citation:
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Assignee:
Banner Pharma Caps, Incorporated
International Classes:
A61K47/34; A61K9/48; A61K47/10; A61K47/32; A61K47/36; A61K47/38
Domestic Patent References:
JP2004530669A2004-10-07
JP2005529104A2005-09-29
JP2003508434A2003-03-04
JPH0386830A1991-04-11
JP2003510267A2003-03-18
JP2002509103A2002-03-26
JPS6322032A1988-01-29
JPH09503495A1997-04-08
JP2003507415A2003-02-25
JP2005514367A2005-05-19
JPH09508128A1997-08-19
JPH11502838A1999-03-09
JPH035418A1991-01-11
Foreign References:
US6027746A2000-02-22
US20040033257A12004-02-19
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Takeshi Oshio