5-アミノ-3H-チアゾロ[4,5-d]ピリミジン-2-オンを調製するための新規な方法

Title:

5-アミノ-3H-チアゾロ[4,5-d]ピリミジン-2-オンを調製するための新規な方法

Document Type and Number:

Japanese Patent JP2009516709

Kind Code:

A

Abstract:

The present invention relates to a process for the preparation of 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one which is a useful intermediate in the preparation of certain thiazolo[4,5-d]pyrimidine nucleosides. The process comprises halogenating 2,4-diaminopyrimidine to form 2,4-diamino-5-halo-pyrimidine and then cyclocondensing the 2,4-diamino-5-halo-pyrimidine to form 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-thione. The 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-thione is then oxidized to afford the 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one.

More Like This:

JP2845341	Title of the Invention N- (3-Hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin) carboxamide derivative
WO/2017/216706	COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
JP4071000	Substitution 1-Aminoalkyl Lactam and Their Use as Muscarin Receptor Antagonists

Inventors:

One, Tinman
Energy, John, S.
Webber, Stefan, Yi.

Application Number:

JP2008541505A

Publication Date:

April 23, 2009

Filing Date:

November 20, 2006

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Anadis Pharmaceuticals, Inc.

International Classes:

C07D513/04

Foreign References:

WO1999051608A1	1999-10-14
WO2005086904A2	2005-09-22
US20050070556A1	2005-03-31
WO1989005649A1	1989-06-29
WO1999051608A1	1999-10-14
WO2005086904A2	2005-09-22

Attorney, Agent or Firm:

Yasuo Yasutomi
Fumio Akiyama

Previous Patent: 液体製剤

Next Patent: ｅＩＦ４Ｅ−ＢＰ２の発現のモジュレート