Title:
抗原特異的エフェクターT細胞の生成法
Document Type and Number:
Japanese Patent JP2009518021
Kind Code:
A
Abstract:
The invention relates to T cells transiently transfected with RNA, especially RNA encoding a T cell receptor and/or FoxP3, and to methods of transfecting T cells with RNA by electroporation. Compositions of the invention include an effector T cell transiently transfected with RNA encoding a T cell receptor (TCR) specific for an antigen, wherein the T cell demonstrates effector function specific for cells presenting the antigen in complex with an MHC molecule. T reg cells comprising an exogenous RNA encoding FoxP3 are also provided. The transfected T cells are useful for immunotherapy, particularly in the treatment of tumors, pathogen infection, autoimmune disease, transplant rejection and graft versus host disease.
Inventors:
Shafts, Neills
Scheller, Gerold
Dorie, Yang
Scheller, Gerold
Dorie, Yang
Application Number:
JP2008543852A
Publication Date:
May 07, 2009
Filing Date:
December 11, 2006
Export Citation:
Assignee:
Argos Therapeutics Incorporated
International Classes:
C12N15/09; A61K35/14; A61K39/00; A61P37/02; C12N5/0783; C12N5/10; A61P31/00; A61P35/00; A61P37/06
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa