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Title:
小分子によるヒト癌におけるGLIタンパク質ターゲティング
Document Type and Number:
Japanese Patent JP2009519909
Kind Code:
A
Abstract:
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.

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Inventors:
Hey, Biao
Fujii, Naoaki
You, Liang
Sue Chidon
Jabrons, David, M.
Application Number:
JP2008544584A
Publication Date:
May 21, 2009
Filing Date:
December 08, 2006
Export Citation:
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Assignee:
The Regents of The University of California
International Classes:
C07D231/14; A61K31/415; A61P35/00; A61P43/00; C12Q1/02; G01N33/15; G01N33/50; C12N15/09
Foreign References:
WO2004106324A12004-12-09
Other References:
JPN6012036490; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．７９，　ｎｏ．２, 2002, ｐ．１９１-１９２
JPN6012036492; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．６９，　ｎｏ．６, 1992, ｐ．３１２-３１３
JPN6012036494; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．ＬＸＩＶ，　ｎｏ．５, 1987, ｐ．３１８-３２１
JPN6012036496; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．ＬＩＩＩ，　ｎｏ．２, 1986, ｐ．２２１-２２２
JPN6012036498; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．ＬＸＩ，　ｎｏ．１１，１２, 1984, ｐ．９７９-９８１
JPN6012036500; Ｊ．　Ｉｎｄｉａｎ　Ｃｈｅｍ．　Ｓｏｃ． ｖｏｌ．ＬＶＩＩＩ，　ｎｏ．２, 1981, ｐ．１６８-１７０
Attorney, Agent or Firm:
Naoto Uchida
Koji Okuhara



 
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