CNS疾患のための4-イミダゾール誘導体の使用

Japanese Patent JP2009524616

A

The present invention relates to methods for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, Ar, R1, R1′, R2, and n are as defined in the specification and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms. The invention also relates to novel compounds of formula I, compositions containing them, and methods for their preparation.

Flounder, Gweed
Grapeke, Tubinden Katrin
Henner, Marius
Norcross, Roger
Henry Starder

JP2008551759A

July 02, 2009

January 17, 2007

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F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

C07D233/58; A61K31/4174; A61K31/4178; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; C07D233/64; C07D403/06; C07D405/06

JPH03133921A	1991-06-07
JPH01294623A	1989-11-28
JPS5632463A	1981-04-01
JP2000007658A	2000-01-11
JP2002080458A	2002-03-19
JPS5818365A	1983-02-02
JPS63150224A	1988-06-22

WO2005034998A2	2005-04-21
WO2006036480A1	2006-04-06

Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito

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