Title:
N-ホルミルヒドロキシルアミン化合物
Document Type and Number:
Japanese Patent JP2009529008
Kind Code:
A
Abstract:
Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
Inventors:
Li Kwanho
Jennifer Leeds
Jennifer Leeds
Application Number:
JP2008557514A
Publication Date:
August 13, 2009
Filing Date:
March 02, 2007
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D401/12; A61K31/4439; A61K31/497; A61K31/501; A61K31/506; A61P31/04; A61P31/06; A61P33/00; A61P33/06; A61P43/00; C07D403/12
Domestic Patent References:
| JP2005502606A | 2005-01-27 |
Foreign References:
| WO2004076053A2 | 2004-09-10 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi